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Antifertility Action and Metabolism of Trimethylphosphate in Rodents

Nature volume 220, pages 591–592 (1968)Cite this article

Abstract

RECENT studies with hexamethylphosphoramide (HMPA) and its analogues have shown that its antifertility activities in insects1 and rodents2 require the presence of all six methyl groups. Thus although pentamethylphosphoramide is a metabolite of HMPA in both the housefly3 and the rodent4 it does not possess significant antifertility activity in either species.

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References

  1. Chang, S. C., Terry, P. H., and Borkovec, A. B., Science, 144, 57 (1964).

    Article  ADS  CAS  Google Scholar 

  2. Jackson, H., and Craig, A. W., Nature, 212, 86 (1966).

    Article  ADS  CAS  Google Scholar 

  3. Chang, S. C., Terry, P. H., Woods, C. W., and Borkovec, A. B., J. Econ. Entomol., 60, 1623 (1967).

    Article  CAS  Google Scholar 

  4. Jones, A. R., and Bertram, J. S., Experientia, 24, 326 (1968).

    Article  CAS  Google Scholar 

  5. Jackson, H., Antifertility Compounds in the Male and Female, 49 (Thomas, Springfield, Illinois, 1966).

    Google Scholar 

  6. Jackson, H., Fox, B. W., and Craig, A. W., J. Reprod. Fertil., 2, 447 (1961).

    Article  CAS  Google Scholar 

  7. Jackson, H., Brit. Med. Bull., 20, 107 (1964).

    Article  CAS  Google Scholar 

  8. Jackson, H., Agents Affecting Fertility, 62 (Biological Council Symposium, J. and A. Churchill, London, 1965).

    Google Scholar 

  9. Cheymol, J., Chabrier, P., Murad, J., and Selim, M., Therapie, 15, 237 (1960).

    CAS  PubMed  Google Scholar 

  10. Vandekov, M., Nature, 179, 154 (1957).

    Article  ADS  Google Scholar 

  11. Deichmann, W. B., and Witherup, S., J. Pharmacol., 88, 338 (1946).

    CAS  Google Scholar 

  12. Jones, F. W., Osborne, G. O., Sutherland, G. J., Topsom, R. D., and Vaughan, J., Chem. Commun., 18 (1966).

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Authors and Affiliations

  1. Unit of Reproductive Pharmacology, University of Manchester,

    H. JACKSON & A. R. JONES

  2. Paterson Laboratories, Christie Hospital, Manchester

    H. JACKSON

Authors
  1. H. JACKSON
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  2. A. R. JONES
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JACKSON, H., JONES, A. Antifertility Action and Metabolism of Trimethylphosphate in Rodents. Nature 220, 591–592 (1968). https://doi.org/10.1038/220591a0

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  • DOI: https://doi.org/10.1038/220591a0

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