Abstract
THE histological changes due to rejection observed after allogenic heart homo transplantation carried out on dogs consist essentially of either scattered ischaemic necrotic areas, or cytoplasmic degeneration leading eventually to massive myocytolysis1–4. These changes are usually delayed and alleviated by therapy, with slight differences according to the treatment used (antilymphocytic serum (ALS), antilymphocytic globulins (ALG) or one immuno-suppressive drug, ‘Azathioprine’). Microscopy has shown that in dogs which died after surviving for a few months the necrotic foci were of different ages and had undergone a series of changes. There are no clinical signs of these successive stages, and so there seems to be justification in looking for biological changes. We report here the results of enzyme determinations made on a series of canine orthotopic transplantations during the course of therapy.
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CLAUVEL, M., SCHWARTZ, K., CRÉPIN, Y. et al. Enzyme Profiles after Heart Transplantation. Nature 220, 483–485 (1968). https://doi.org/10.1038/220483a0
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DOI: https://doi.org/10.1038/220483a0
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