Abstract
MOVEMENT of protein molecules within and across the plasma membranes of mammalian cells probably occurs more widely than is generally realized. Examples of protein transport that are not normally considered in the same light include the supposed movement of “carrier” proteins within the plasma membrane1, the penetration of albumin into isolated tumour cells2 and the endocytosis of proteins by the epithelium of the small intestine3. Yet the protein–membrane interactions which probably accompany the movement of protein molecules in each case are likely to have certain features in common. For example, transported protein must show some temporary affinity for constituents of the membrane, and the actual movement of protein across the membrane will cause some distortion of otherwise stable structures. The experiments described here were designed to test whether the transport of protein by the pig intestinal mucosa was in any way similar to the transport of protein into tumour cells, a system which has been used extensively to study some of the macromolecular interactions associated with protein transport2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Crane, R. K., in Intracellular Transport, 71 (Academic Press, London, 1966).
Ryser, H. J.-P., Science, 159, 390 (1968).
Morris, I. G., in Handbook of Physiology—Alimentary Canal, 3, 1491 (American Physiological Society, Washington DC, 1968).
Krebs, H. A., and Henseleit, K., Hoppe-Seyler's Z. Physiol. Chem., 210, 33 (1932).
Pierce, A. E., and Smith, M. W., J. Physiol., 190, 19 (1967).
Brown, P., Smith, M. W., and Witty, R., J. Physiol., 198, 365 (1968).
Hansen, O., Scand. J. Clin. Lab. Invest., 14, 651 (1962).
Gell, P. G. H., J. Clin. Pathol., 10, 67 (1957).
Dixon, W. J., and Massey, F. J., in Introduction to Statistical Analysis, 488 (McGraw–Hill, New York, 1957).
Rice, R. V., Stahmann, M. A., and Alberty, R. A., J. Biol. Chem., 209, 105 (1954).
Ryser, H. J.-P., Nature, 215, 934 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SMITH, M., WITTY, R. & BROWN, P. Effect of Poly-L-arginine on Rate of Bovine IgG Transport by Newborn Pig Intestine. Nature 220, 387–388 (1968). https://doi.org/10.1038/220387a0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1038/220387a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.