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Crystallographic Data for the Fab Fragment of a Human Myeloma Immunoglobulin

Nature volume 220, pages 1248–1249 (1968)Cite this article

Abstract

COMPARISONS of the physical properties and chemical structure of myeloma proteins with those of other immunoglobulins and antibodies have indicated that myeloma proteins are abnormal only in their relative homogeneity; they seem to be typical representatives of the immunoglobulin class to which they belong. In addition, antibody activity has been shown in several myeloma proteins and in macroglobulins associated with Waldenstrom's syndrome1–9. A knowledge of the tertiary structure of fragment Fab, which contains the combining site of an antibody10, should therefore be of particular interest.

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References

  1. Kritzman, J., Kunkel, M. G., McCarthy, J., and Mellors, R. C., J. Lab. Clin. Med., 57, 905 (1961).

    CAS  PubMed  Google Scholar 

  2. Waldenstrom, J., Winblad, S., Hällén, J., and Livingman, S., Acta Med. Scand., 176, 619 (1964).

    Article  Google Scholar 

  3. Beaumont, J. L., Jocotot, B., Vilain, C., and Baumont, V., CR Acad. Sci., 260, 5960 (1965).

    CAS  Google Scholar 

  4. Curtain, C. C., Baumgarten, A., and Pye, J., Arch. Biochem. Biophys., 112, 37 (1965).

    Article  CAS  Google Scholar 

  5. Balazs, V., and Frohlich, M. M., Amer. J. Med. Sci., 252, 669 (1966).

    Google Scholar 

  6. Metzger, H., Proc. US Nat. Acad. Sci., 57, 1490 (1967).

    Article  ADS  CAS  Google Scholar 

  7. Eisen, H. N., Little, J. R., Osterland, C. K., and Simms, E. S., Cold Spring Harbor Symp. Quant. Biol., 32, 75 (1967).

    Article  CAS  Google Scholar 

  8. Cohn, M., Cold Spring Harbor Symp. Quant. Biol., 32, 211 (1967).

    Article  CAS  Google Scholar 

  9. Potter, M., and Leon, M. A., Science, 162, 369 (1968).

    Article  ADS  CAS  Google Scholar 

  10. Porter, R. R., Biochem. J., 73, 119 (1959).

    Article  CAS  Google Scholar 

  11. Rossi, G., and Nisonoff, A., Biochem. Biophys. Res. Commun., 31, 914 (1968).

    Article  CAS  Google Scholar 

  12. Edelman, G. M., Heremans, J. F., Heremans, M. Th., and Kunkel, H. G., J. Exp. Med., 112, 203 (1960).

    Article  CAS  Google Scholar 

  13. Edelman, G. M., and Poulik, M. D., J. Exp. Med., 113, 861 (1961).

    Article  CAS  Google Scholar 

  14. Poljak, R. J., Goldstein, D. J., Humphrey, R. L., and Dintzis, H. M., Cold Spring Harbor Symp. Quant. Biol., 32, 95 (1967).

    Article  CAS  Google Scholar 

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Author notes

  1. G. ROSSI: On leave from the Institute of General Pathology, University of Naples, Italy.

Authors and Affiliations

  1. Department of Biophysics, Johns Hopkins University, School of Medicine, Baltimore, Maryland

    H. P. AVEY & R. J. POLJAK

  2. Department of Microbiology, College of Medicine, University of Illinois,

    G. ROSSI & A. NISONOFF

Authors
  1. H. P. AVEY
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  2. R. J. POLJAK
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  3. G. ROSSI
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  4. A. NISONOFF
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AVEY, H., POLJAK, R., ROSSI, G. et al. Crystallographic Data for the Fab Fragment of a Human Myeloma Immunoglobulin. Nature 220, 1248–1249 (1968). https://doi.org/10.1038/2201248a0

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