Role of the LDH-elevating Virus in Leukaemia Therapy by Asparaginase

Abstract

THE dramatic cure of certain leukaemia and lymphomas in mice by the administration of the enzyme L-asparaginase1–4 has led to an extensive clinical evaluation of this therapy in patients with leukaemia and other forms of cancer. Unfortunately, the results so far in human beings have not compared favourably with those obtained in mice, although significant temporary remissions have been obtained in a substantial number of patients5–7. It is important to examine the mechanism of action of asparaginase in the hope that the curative effects on disseminated neoplasms in mice might also be realized for other species.

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RILEY, V. Role of the LDH-elevating Virus in Leukaemia Therapy by Asparaginase. Nature 220, 1245–1246 (1968). https://doi.org/10.1038/2201245b0

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