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Genetic Background of Circadian Rhythms

Abstract

CIRCADIAN rhythms1–3 have not yet been investigated in twins. The mathematical methods used in one-phase examinations of twins—variance analysis4,5, cross-twin analysis or intra-subject correlation—are not suitable for expressing the concordance or discordance of a certain biological phenomenon in time between the individuals of separate twin pairs. We have therefore tried to devise a method of our own, suitable both for the basal physiological research of medical genetics, and for the study of biological rhythms, for example, in human biometeorology.

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References

  1. Therap. Notes, 64/4, 94 (1967).

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  3. Halberg, F., Good, R. A., and Levine, H., Circulation, 34/5 715 (1966).

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  4. Barcal, R., Matousek, J., Sova, J., Third Czechoslovakian Congr. Medical Genetics, Plzen (1967); Plzen. Lek. Sborn., suppl. 22, 109 (1968).

  5. Osborne, R. H., and De George, F. V., Genetic Basis of Morphological Variation, An Evaluation and Application of the Twin Study Method (Harvard University Press, Cambridge, Massachusetts, 1959).

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BARCAL, R., SOVA, J., KRIZANOVSKA, M. et al. Genetic Background of Circadian Rhythms. Nature 220, 1128–1131 (1968). https://doi.org/10.1038/2201128a0

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  • DOI: https://doi.org/10.1038/2201128a0

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