Abstract
A decrease of 5-hydroxytryptamine in the brain after peripheral injection of hydrocortisone may be mediated through increased activity of tryptophan pyrrolase in the liver. This suggests a relationship between biochemical changes in depressive disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Grahame-Smith, D. G., Biochem. Biophys. Res. Commun., 16, 586 (1964).
Valzelli, L., and Garattini, S., J. Neurochem., 15, 259 (1968).
Knox, W. E., and Auerbach, V. H., J. Biol. Chem., 214, 307 (1955).
Jerome, H., Lejeune, J., and Turpin, R., CR Acad. Sci., 251, 474 (1960).
Curzon, G., in Biochemical Aspects of Neurological Disorders, ser. 2 (edit. by Cumings, J. N., and Kremer, M.), 257 (Blackwell, Oxford, 1965).
Becking, G. C., and Johnson, W. L., Canad. J. Biochem., 45, 1667 (1967).
Rapoport, M. I., Feigin, R. D., Bruton, J., and Beisel, W. R., Science, 153, 1642 (1966).
Scheving, L. E., Harrison, W. H., Gordon, P., and Pauly, J. E., Amer. J. Physiol., 214, 166 (1968).
Curzon, G., and Green, A. R., Life Sci., 7, 657 (1968).
Snyder, S. H., Axelrod, J., and Zweig, M., Biochem. Pharmacol., 14, 831 (1965).
Chytil, F., J. Biol. Chem., 243, 893 (1968).
Elion, G. B., Callahan, S., Nathan, H., Bieber, S., Rundles, R. W., and Hitchings, G. H., Biochem. Pharmacol., 12, 85 (1963).
Giacalone, E., and Valzelli, L., J. Neurochem., 13, 1265 (1966).
McCollister, R. J., Gilbert, W. R., Ashton, D. M., and Wyngaarden, J. B., J. Biol. Chem., 239, 1560 (1964).
Seegmiller, J., Proc. Roy. Soc. Med., 59, 291 (1966).
Skipper, H. E., Robins, R. K., Thomson, J. R., Cheng, C. C., Brockman, R. W., and Schabel, F. M., Cancer Res., 17, 579 (1957).
Knox, W. E., Piras, M. M., and Tokuyama, K., J. Biol. Chem., 241, 297 (1966).
Pomales, R., Bieber, S., Friedman, R., and Hitchings, G. H., Biochim. Biophys. Acta, 72, 119 (1963).
Sourkes, T. L., Missala, K., and Madras, B. K., J. Pharmacol. (in the press).
Civen, M., and Knox, W. E., J. Biol. Chem., 235, 1716 (1960).
Coppen, A., Shaw, D. M., Herzberg, B., and Maggs, R., Lancet, ii, 1178 (1967).
Persson, T., and Roos, B. E., Lancet, ii, 987 (1967).
Hertz, D., and Sulman, F. G., Lancet, i, 531 (1968).
Praag, H. M. van, and Leijnse, B., Psychopharmacologia, 4, 1 (1963).
Ashcroft, G. W., Crawford, T. B. B., Eccleston, D., Sharman, D. F., MacDougall, E. J., Stanton, J. B., and Binar, J. K., Lancet, ii, 1049 (1966).
Shaw, D. M., Camps, F. E., and Eccleston, E. G., Brit. J. Psychiat., 113, 1407 (1967).
Cazzullo, C. L., Mangori, H., and Masherpa, D., Brit. J. Psychiat., 112, 157 (1966).
Rubin, R. T., Arch. Gen. Psychiat., 17, 671 (1967).
Knapp, M. S., Keane, P. M., and Wright, J. G., Brit. Med. J., ii, 27 (1967).
Torda, C., Brain Res., 6, 375 (1967).
Albrecht, P., Visscher, M. B., Bettner, J. J., and Halberg, F., Proc. Soc. Exp. Biol. and Med., 92, 703 (1956).
Altman, K., and Greengard, O., J. Clin. Invest., 45, 1527 (1966).
Corrodi, H., Fuxe, K., and Hökfelt, T., Life Sci., 7, 107 (1968).
Eccleston, D., Ashcroft, G. W., Crawford, T. B. B., and Loose, R., J. Neurochem, 13, 93 (1966).
Dewhurst, W. G., Nature, 218, 1130 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GREEN, A., CURZON, G. Decrease of 5-Hydroxytryptamine in the Brain provoked by Hydrocortisone and its Prevention by Allopurinol. Nature 220, 1095–1097 (1968). https://doi.org/10.1038/2201095a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2201095a0
This article is cited by
-
Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus
Neurochemical Research (2016)
-
Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5‐HT in the UK
British Journal of Pharmacology (2008)
-
Differential pulse voltammetry in vivo with working carbon fiber electrodes: 5-hydroxyindole compounds or uric acid detection?
Experimental Brain Research (1986)
-
Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
