Abstract
DRUGS and other compounds capable of causing sustained trembling are rare; in a survey of ten thousand compounds Everett et al. found less than ten with this property1. One of the best known is tremorine (1,4-dipyrrolidine-2-butyne) which is converted into a more active compound, oxotremorine2, by body tissues. Various synthetic amino alcohols also stimulate prolonged tremors, but their mechanism of action differs from that of tremorine and other more familiar compounds3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Everett, G. M., Blockus, L. E., and Shepperd, I. M., Science, 124, 79 (1956).
Hammer, W., Karlen, B., Rane, A., and Sjoquist, F., Life Sci., 7, 197 (1968).
Ahmed, A., Marshall, P. B., and Shepherd, D. M., J. Pharm. Pharmacol., 10, 672 (1958).
Wilson, B. J., and Wilson, C. H., Science, 144, 177 (1964).
Wilson, B. J., Bact. Rev., 30, 478 (1966).
Holzapfel, C. W., Tetrahedron, 24, 2101 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WILSON, B., WILSON, C. & HAYES, A. Tremorgenic Toxin from Penicillium cyclopium grown on Food Materials. Nature 220, 77–78 (1968). https://doi.org/10.1038/220077b0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/220077b0
This article is cited by
-
Artificial antigen synthesis and the development of polyclonal antibody-based immunoassay for citreoviridin determination
World Journal of Microbiology and Biotechnology (2014)
-
Tremorgenic mycotoxins produced by strains of Penicillium spp. isolated from toxic Poa huecu parodi
Mycopathologia (1992)
-
Aspergillus clavatus as the probable cause of a lethal mass neurotoxicosis in sheep
Mycopathologia (1991)
-
The connection between the Penicillia and Aspergilli and mycotoxins with special emphasis on misidentified isolates
Archives of Environmental Contamination and Toxicology (1989)
-
A simple colorimetric method for screening cyclopiazonic acid in agricultural commodities
Mycopathologia (1987)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.