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Immunology and Biochemistry of Regan Isoenzyme of Alkaline Phosphatase in Human Cancer

Abstract

Derepression of the genome of the cancer cell may explain why certain cancer patients exhibit an isoenzyme of alkaline phosphatase biochemically and immunologically indistinguishable from human placental alkaline phosphatase.

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References

  1. 1

    Fishman, W. H., Inglis, N. R., Stolbach, L. L., and Krant, M. J., Cancer Res., 28, 150 (1968).

    CAS  PubMed  Google Scholar 

  2. 2

    Fishman, W. H., Inglis, N. R., and Ghosh, N. K., Clin. Chim. Acta, 19, 71 (1968).

    CAS  Article  Google Scholar 

  3. 3

    Fishman, W. H., and Ghosh, N. K., in Adv. in Clinical Chemistry, 10, 255 (1967).

    Google Scholar 

  4. 4

    Griffin, M. J., and Cox, R. R., Proc. US Nat. Acad. Sci., 56, 946 (1966).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Lancet, i, 317 (1964); ibid., i, 86 (1967).

  6. 6

    New Eng. J. Med., 278, 1016 (1968).

  7. 7

    Ghosh, N. K., and Fishman, W. H., Biochem. J. (in the press).

  8. 8

    Reif, A. E., and Norris, H. J., Cancer Res., 20, 1235 (1960).

    CAS  PubMed  Google Scholar 

  9. 9

    Hoppe, H. E., Bernheim, B. C., Nisalak, A., Tjio, J. H., and Smadel, J. E., J. Immunol., 91, 416 (1963).

    Google Scholar 

  10. 10

    Hayflick, L., and Moorhead, P. S., Exp. Cell Res., 25, 585 (1961).

    CAS  Article  Google Scholar 

  11. 11

    Boyer, S. H., Ann. NY Acad. Sci., 103, 938 (1963).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Fishman, W. H., Green, S., and Inglis, N. R., Nature, 198, 685 (1963).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Fishman, W. H., and Green, S., Enzymologia, 33, 89 (1967).

    CAS  Google Scholar 

  14. 14

    Fishman, W. H., Ghosh, N. K., Inglis, N. R., and Green, S., Enzymologia (in the press).

  15. 15

    Green, S., Giovanniello, T. J., Cote, R. A., and Fishman, W. H., Automation in Analytical Chemistry, Technicon Symposia, 1, 563 (1967).

    Google Scholar 

  16. 16

    Lipsett, M. B., Cancer Res., 25, 1068 (1965).

    CAS  PubMed  Google Scholar 

  17. 17

    Bower, B. F., and Gordan, G. S., Ann. Rev. Med., 16, 83 (1965).

    CAS  Article  Google Scholar 

  18. 18

    Hobbs, C. B., and Miller, A. L., J. Clin. Pathol., 19, 119 (1966).

    CAS  Article  Google Scholar 

  19. 19

    Tatarinov, Y. S., Vopr. Med. Khimii, 11 (2), 20 (1965).

    CAS  PubMed  Google Scholar 

  20. 20

    Alpert, M. E., Uriel, J., and deNechaud, B., New Engl. J. Med., 278, 984 (1968).

    CAS  Article  Google Scholar 

Download references

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FISHMAN, W., INGLIS, N., GREEN, S. et al. Immunology and Biochemistry of Regan Isoenzyme of Alkaline Phosphatase in Human Cancer. Nature 219, 697–699 (1968). https://doi.org/10.1038/219697a0

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