Abstract
RESTRICTION of phage multiplication by transferable resistance factors (R factors), or by the transfer factors responsible for their mobility, has been recognized for some years in Escherichia coli K12 (=K12) and in salmonellae1–7. Although this restriction prevents multiplication of the affected phages, they are usually adsorbed, and the barrier to their multiplication is intracellular. Their deoxyribonucleic acid enters the cell and may undergo degradation6. The restriction can be overcome by host-induced modification1,3,4,6, or by host-range mutation of the phages7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Yoshikawa, M., and Akiba, T., Jap. J. Microbiol., 6, 120 (1962).
Watanabe, T., Nishida, H., Ogata, C., Arai, T., and Sato, S., J. Bact., 88, 716 (1964).
Molina, A. M., Giorn. Microbiol., 12, 107 (1964).
Arber, W., and Morse, M. L., Genetics, 51, 137 (1965).
Anderson, E. S., and Lewis, M. J., Nature, 208, 843 (1965).
Watanabe, T., Takano, T., Arai, T., Nishida, H., and Sato, S., J. Bact., 92, 477 (1966).
Anderson, E. S., Nature, 212, 795 (1966).
Anderson, E. S., Eighteenth Symp. Soc. Gen. Microbiol., 343 (Cambridge University Press, London, 1968).
Anderson, E. S., and Williams, R. E. O., J. Clin. Path., 9, 94 (1956).
Anderson, E. S., Kelemen, M. V., Jones, C. M., and Pitton, J.-S., Genet. Res. Comb., 11, 119 (1968).
Callow, B. R., J. Hyg., Camb., 57, 346 (1959).
Felix, A., and Callow, B. R., Brit. Med. J., ii, 127 (1943).
Felix, A., and Callow, B. R., Lancet, ii, 10 (1951).
Felix, A., J. Gen. Microbiol., 14, 208 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ANDERSON, E., PITTON, JS. & MAYHEW, J. Restriction of Bacteriophage Multiplication by Resistance Determinants in Salmonellae. Nature 219, 640–641 (1968). https://doi.org/10.1038/219640a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/219640a0
This article is cited by
-
Construction of plasmid-free derivatives ofSalmonella typhimurium LT2 using temperature-sensitive mutants of pKZ1 for displacement of the resident plasmid, pSLT
Molecular and General Genetics MGG (1990)
-
Genetic and molecular characterisation of some non-transferring plasmids
Molecular and General Genetics MGG (1974)
-
Molecular studies of an fi + plasmid from strains of Salmonella typhimurium
Molecular and General Genetics MGG (1973)
-
Transfer of a Neomycin–Kanamycin Resistance Determinant by the F Factor of Escherichia coli K12
Nature (1969)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
