Abstract
SUTHERLAND and his collaborators have firmly established that the cyclic nucleotide, adenosine 3′,5′-monophosphate (CAMP), is a ubiquitous regulator of a variety of intracellular processes1. Its role in the activation of phosphorylase has been elucidated by Sutherland and Rall2. It is now almost certain that CAMP also participates in the activation of lipase in adipose tissue3, and may affect the activity of such key regulator enzymes as phosphofructokinase4,5. Furthermore, CAMP has been implicated as the intracellular mediator of a variety of hormonal effects ranging from steroidogenesis in the corpus luteum and adrenal cortex to increased water permeability in toad bladder and kidney tubules1.
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GOODMAN, H. Proposed Mode of Action of Histamine. Nature 219, 1053 (1968). https://doi.org/10.1038/2191053a0
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DOI: https://doi.org/10.1038/2191053a0
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