Abstract
ACTIVITY of tyrosine transaminase in the rat liver1 and the concentration of corticosterone in the rodent adrenal gland2 both vary according to the time of the day. The steroid concentrations are highest around the beginning of the daily dark period, and the hepatic enzyme shows peak activity several hours later1,2. Shifts in the timing of the daily light period cause parallel changes in the phasing of both rhythms after several days3,4. Because exogenous glucocorticoids increase the activity of tyrosine transaminase in experimental animals5,6, at first it seemed likely that the enzyme cycle was generated by rhythmic changes in the plasma concentration of corticosterone. Subsequently, however, the tyrosine transaminase rhythm was shown to persist in animals the adrenal secretory rhythms of which had been extinguished by hypophysectomy or bilateral adrenalectomy1,7.
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WURTMAN, R., SHOEMAKER, W., LARIN, F. et al. Failure of Brain Norepinephrine Depletion to extinguish the Daily Rhythm in Hepatic Tyrosine Transaminase Activity. Nature 219, 1049–1050 (1968). https://doi.org/10.1038/2191049a0
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DOI: https://doi.org/10.1038/2191049a0
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