Abstract
THE predominant haemoglobin in the blood of most human adults is type A, a tetrameric haemo-protein composed of two pairs of identical polypeptide chains—alpha and beta chains—inherited as nonallelic autosomal dominant traits1. I have found a family of African Negro origin which possesses four different major haemoglobins (Fig. 1): Hb A, S, C and E. These were identified preliminarily by their characteristic electrophoretic mobilities in starch gel at pH 8.6 (Fig. 1)2; the appearance of Hb C or E on starch was verified by agar gel electrophoresis at pH. 6.2 (Fig. 1)3, and appearance of Hb S was verified by deoxygenation of samples of whole blood with sodium metabisulphite : this causes Hb S to polymerize, distorting the erythrocytes into rigid, elongate forms known as sickle cells4,5.
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References
Itano, H. A., Adv. Prot. Chem., 12, 215 (1957).
Smithies, O., Biochem. J., 71, 585 (1959).
Marder, V., and Conley, C. L., Bull. Johns Hopkins Hosp., 105, 77 (1959).
Herrick, J. B., Arch. Intern. Med., 6, 517 (1910).
Harris, J. W., Proc. Soc. Exp. Biol. and Med., 75, 197 (1950).
Ingram, V. M., Biochim. Biophys. Acta, 36, 402 (1959).
Hunt, J. A., and Ingram, V. M., Nature, 184, 1062 (1958).
Hunt, J. A., and Ingram, V. M., Nature, 184, 870 (1959).
Huisman, T. H., J. Lab. clin. Med., 52, 312 (1958).
Field, E. O., and O'Brien, J. R. P., Biochem. J., 60, 656 (1955).
Ranney, H., J. Clin. Invest., 33, 1634 (1954).
Smith, E. W., and Conley, C. L., Bull. Johns Hopkins Hosp., 94, 289 (1954).
Kunkel, H. G., J. Clin. Invest., 36, 1615 (1957).
Daland, G., and Castle, W. B., J. Lab. Clin. Med., 33, 1082 (1948).
Aksoy, M., Blood, 15, 610 (1960).
Chernoff, A., J. Lab. Clin. Med., 47, 455 (1956).
Ingram, V. M., Biochim. Biophys. Acta, 28, 539 (1958).
Rieder, R. F., Amer. J. Med., 39, 4 (1965).
Wintrobe, M., Clinical Hematology, 606 (Lea and Febiger, Philadelphia, 1967).
Itano, H. A., Arch. Biochem. Biophys., 47, 148 (1953).
Smith, E. W., and Krevans, J. R., Bull. Johns Hopkins Hosp., 104, 17 (1959).
Diggs, L. W., Blood, 9, 1172 (1954).
Conley, C. L., Medicine, 43, 785 (1964).
Harris, J. W., Prog. Hematol., 2, 47 (1959).
Singer, K., and Singer, L., Blood, 8, 1008 (1953).
Allison, A. C., Biochem. J., 65, 212 (1957).
Charache, S., and Conley, C. L., Blood, 24, 25 (1964).
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ROSENBERG, M. In vivo and in vitro Interactions of Human Haemoglobins A, S and C with a Variant Haemoglobin E. Nature 219, 1042–1044 (1968). https://doi.org/10.1038/2191042a0
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DOI: https://doi.org/10.1038/2191042a0
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