Abstract
RECENT research (see refs. 1–3) has shown that 17β-oestradiol is specifically taken up and retained, without detectable chemical transformation, by uterus, vagina, adenohypophysis, mammary gland4 and hypothalamus5. In contrast, other organs rapidly release or transform it. In target tissues most of the hormone is found in the nuclear fraction—up to 80 per cent, depending on the homogenization conditions—and the rest is mostly in the 105,000g supernatant6–10. Toft and Gorsky11,12 found that the hormone in the supernatant is bound in larger part to a macromolecule (9.5S) which, at least in part, consists of protein and has the properties of a specific receptor for oestrogens, that is, it shows a high affinity and specificity for oestrogenic molecules.
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References
Jensen, E. V., in Biological Activities of Steroids in Relation to Cancer (edit. by Pincus, G., and Vollmer, E. P.), 161 (Academic Press, New York, 1960).
Jensen, E. V., in Rec. Prog. Hormone Res., 18, 387 (1962).
Jensen, E. V., in Canad. Cancer Conf., 6, 143 (1966).
Bresciani, F., and Puca, G. A., Atti IX Cong. Soc. Ital. Patol., 9, 653 (1965).
Eisenfeld, A. J., and Axelrod, J., Endocrinology, 79, 38 (1966).
Talwar, G. P., Segal, S. J., Evans, A., and Davidson, O. W., Proc. US Nat. Acad. Sci., 52, 1059 (1964).
Jensen, E. V., in Proc. Second Intern. Cong. Endocrinol., London, 1964, 420 (Excerpta Medica Foundation, Amsterdam).
Noteboom, W. D., and Gorski, J., Arch. Biochem. Biophys., 111, 559 (1965).
King, R. J. B., and Gordon, J., J. Endocrinol., 34, 431 (1966).
Puca, G. A., Orii, H., and Fragomele, F., Atti X Congr. Soc. Ital. Patol., 10 (in the press).
Toft, D., and Gorski, J., Proc. US Nat. Acad. Sci., 55, 1574 (1966).
Toft, D., Shyamala, G., and Gorski, J., Proc. US Nat. Acad. Sci., 57, 1740 (1967).
Jensen, E. V., Hurst, D. J., Desombre, E. R., and Jungblut, P. W., Science, 158, 385 (1967).
Sandberg, A. A., and Slaunwhite, jun., W. R., J. Clin. Invest., 36, 1266 (1957).
Duncan, G. W., Lyster, S. C., Clark, J. J., and Lednicer, D., Proc. Soc. Exp. Biol. (NY), 112, 439 (1963).
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PUCA, G., BRESCIANI, F. Receptor Molecule for Oestrogens from Rat Uterus. Nature 218, 967–969 (1968). https://doi.org/10.1038/218967a0
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DOI: https://doi.org/10.1038/218967a0
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