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Relationship between Membrane Voltage and Tension in Voltage-clamped Cardiac Purkinje Fibres

Nature volume 218, pages 588–589 (1968)Cite this article

Abstract

MOST quantitative information relating membrane voltage to contractile force in muscle has so far been obtained by examining the contracture produced when muscle is depolarized by high external concentrations of potassium. Thus depolarized, skeletal and ventricular fibres begin to develop force at a membrane voltage of about −55 mV; force is then proportional to the degree of depolarization to a membrane voltage of −25 mV (refs. 3 and 4).

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Authors and Affiliations

  1. Department of Medicine and Physiology, University of Chicago, Chicago, Illinois

    H. A. FOZZARD

  2. Department of Medicine, Washington University, St Louis, Missouri

    D. C. HELLAM

Authors
  1. H. A. FOZZARD
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  2. D. C. HELLAM
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FOZZARD, H., HELLAM, D. Relationship between Membrane Voltage and Tension in Voltage-clamped Cardiac Purkinje Fibres. Nature 218, 588–589 (1968). https://doi.org/10.1038/218588a0

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