N -Methyl - N - nitrosourethane (NMU), CH3.N(NO).CO.OC2H5, and N - methyl - N - nitroso - N′ - nitroguanidine (NNMG), CH3.N(NO).C(:NH).NHNO2, are well known mutagens and carcinogens. It seemed likely that these compounds could act as methylating agents, and furthermore, methylation of DNA could be significant in determining their biological action.
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Schoental, R., Biochem. J., 102, 5C (1967).
Rau, J., and Lingens, F., Naturwissenschaften, 54, 517 (1967).
Singer, B., and Fraenkel-Conrat, H., Proc. US Nat. Acad. Sci., 58, 234 (1967).
Chandra, P., Wacker, A., Süssmuth, R., and Lingens, F., Z. Naturforschung., 22b, 512 (1967).
Lawley, P. D., and Brookes, P., Biochem. J., 89, 127 (1963).
Bardos, T. J., Datta-Gupta, N., Hebborn, P., and Triggle, D. J., J. Med. Chem., 8, 167 (1965).
Pullman, B., and Pullman, A., Biochim. Biophys. Acta, 36, 343 (1959).
Kriek, E., and Emmelot, P., Biochim. Biophys. Acta., 91, 59 (1964); Biochemistry, 2, 733 (1963).
Gutsche, C. D., and Johnson, H. E., J. Amer. Chem. Soc., 77, 109 (1955).
Haines, J. A., Reese, C. B., and Todd, A. R., J. Chem. Soc., 5281 (1962).
Krieg, D. R., Nucleic Acid Res., 2, 125 (1963).
Lawley, P. D., Prog. Nucleic Acid Res. and Mol. Biol., 5, 89 (1966); Lawley, P. D., in Molekulare Biologie des Malignen Wachstums, 126 (Springer-Verlag, Berlin, 1966).
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LAWLEY, P. Methylation of DNA by N-Methyl-N-nitrosourethane and N-Methyl-N-nitroso-N′-nitroguanidine. Nature 218, 580–581 (1968). https://doi.org/10.1038/218580a0
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