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Estimate of Loss of Labile Body Nitrogen during Acute Protein Deprivation in Young Adults

Abstract

THE concept and origin of labile body protein that can be reversibly depleted and repleted have already been reviewed in detail1,2. The feeding of a protein-free diet which is adequate in calories results in a rapid decline in the rate of excretion of urinary nitrogen until a low and relatively steady rate is obtained. This level is regarded as the obligatory or endogenous loss of urinary nitrogen and the additional nitrogen above this level, lost during the first few days on a protein-free diet, has been considered to represent the loss of labile body protein. Although it has been suggested that the nitrogen store is present as non-protein nitrogen3,4, the best evidence indicates that it is probably cytoplasmic in origin, with enzymes contributing to the labile protein pool5,6.

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References

  1. Munro, H. N., in Mammalian Protein Metabolism (edit. by Munro, H. N., and Allison, J. B.), 1, chap. 10 (Academic Press, Inc., New York, 1964).

    Google Scholar 

  2. Fisher, H., in Newer Methods of Nutritional Biochemistry (edit. by Albanese, A. A.), 3, chap. 2 (Academic Press, Inc., New York, 1967).

    Google Scholar 

  3. Wessels, J. P. H., and Fisher, H., Brit. J. Nutrit., 19, 57 (1965).

    Article  CAS  Google Scholar 

  4. Fisher, H., Brush, M. K., Griminger, P., and Sotsman, E. R., Amer. J. Clin. Nutrit., 20, 927 (1967).

    Article  CAS  Google Scholar 

  5. Allison, J. B., Amer. J. Clin. Nutrit., 4, 662 (1956).

    Article  CAS  Google Scholar 

  6. Patwardhan, V. N., Fed. Proc., 20, 73 (1961).

    CAS  PubMed  Google Scholar 

  7. Campbell, R. M., and Kosterlitz, H. W., Biochem. J., 43, 416 (1948).

    Article  CAS  Google Scholar 

  8. Allison, J. B., and Wannemacher, R. W., Amer. J. Clin. Nutrit., 16, 445 (1965).

    Article  CAS  Google Scholar 

  9. Voit, C. (1866), cited by Munro in Mammalian Protein Metabolism, (edit. by Munro, H. N., and Allison, J. B.), 1, 383 (Academic Press, Inc., New York, 1964).

    Google Scholar 

  10. Gopalan, C., and Narasinga Rao, B. S., J. Nutrit., 90, 213 (1966).

    CAS  PubMed  Google Scholar 

  11. Young, V. R., and Scrimshaw, N. S., Brit. J. Nutrit., 22, 9 (1968).

    Article  CAS  Google Scholar 

  12. Evans, R. D., Radium and Mesothorium Poisoning and Dosimetry and Instrumentation Techniques in Applied Radioactivity, Section C, Annual Progress Report, Contract AT (30–1)–952 (US Atomic Energy Commission, Division of Biology and Medicine, May, 1966).

    Google Scholar 

  13. Bricker, M. L., and Smith, J. N., J. Nutrit., 44, 553 (1951).

    CAS  PubMed  Google Scholar 

  14. Duel, H. J., Sandiford, I., Sandiford, K., and Boothby, W. M., J. Biol. Chem., 76, 391 (1928).

    Google Scholar 

  15. Basak, M., Indian J. Med. Res., 43, 307 (1958).

    Google Scholar 

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YOUNG, V., HUSSEIN, M. & SCRIMSHAW, N. Estimate of Loss of Labile Body Nitrogen during Acute Protein Deprivation in Young Adults. Nature 218, 568–569 (1968). https://doi.org/10.1038/218568a0

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