Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Active Intestinal Absorption of L-Glucose

Nature volume 218, pages 473–474 (1968)Cite this article

Abstract

IN their study of the effect of amino-acids on the intestinal absorption of sugars in normal hamsters, Hindmarsh, Kilby and Wiseman1 observed that although L-glucose was not transported against its concentration gradient, its absorption down its concentration gradient was markedly reduced by L-histidine. They concluded that L-glucose probably participated in an active transport system. In order to investigate this problem further, we have carried out experiments using sacs2,3 of everted mid-small intestine from rats kept on a restricted diet (6–10 g food/day for 9 days); on such a diet this species shows enhanced active absorption of D-glucose and L-histidine4,5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hindmarsh, J. T., Kilby, D., and Wiseman, G., J. Physiol., 186, 166 (1966).

    Article  CAS  Google Scholar 

  2. Wilson, T. H., and Wiseman, G., J. Physiol., 123, 116 (1954).

    Article  CAS  Google Scholar 

  3. Wiseman, G., Methods in Medical Research (edit. by Quastel, J. H.), 9, 287 (Year Book Medical Publishers, Chicago, 1961).

    Google Scholar 

  4. Kershaw, T. G., Neame, K. D., and Wiseman, G., J. Physiol., 152, 182 (1960).

    Article  CAS  Google Scholar 

  5. Hindmarsh, J. T., Kilby, D., Ross, B., and Wiseman, G., J. Physiol., 188, 207 (1967).

    Article  CAS  Google Scholar 

  6. Wilson, T. H., Fed. Proc., 17, 337 (1958).

    Google Scholar 

  7. Csáky, T. Z., and Fernald, G. W., Amer. J. Physiol., 198, 445 (1960).

    Article  Google Scholar 

  8. Krebs, H. A., and Henseleit, K., Hoppe-Seyl. Z. Physiol. Chem., 210, 33 (1932).

    Article  CAS  Google Scholar 

  9. Nelson, N., J. Biol. Chem., 153, 375 (1944).

    CAS  Google Scholar 

  10. Huggett, A. St. G., and Nixon, D. A., Lancet, ii, 368 (1957).

  11. Wilson, T. H., Intestinal Absorption, 88 (Saunders, Philadelphia, London, 1962).

  12. Wiseman, G., Absorption from the Intestine, 25 (Academic Press, London, New York, 1964).

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Sheffield,

    R. J. NEALE & G. WISEMAN

Authors
  1. R. J. NEALE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. WISEMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

NEALE, R., WISEMAN, G. Active Intestinal Absorption of L-Glucose. Nature 218, 473–474 (1968). https://doi.org/10.1038/218473a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/218473a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing