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Relative Rates of Synthesis of Immunoglobulins and Light Chains in Rabbit Spleen Cells during Secondary Response

Abstract

LYMPH node cells of immunized rabbit have been shown to produce not only whole molecules of immunoglobulins (Ig), but also an excess of L-chains1–3. Other data suggest a small pool of light chains with a rapid turnover4. Rabbit spleen cells have also been found to synthesize a micro-globulin with antigenic determinants of both light and heavy chains in vitro2,3.

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SKVORTSOV, V., GURVICH, A. Relative Rates of Synthesis of Immunoglobulins and Light Chains in Rabbit Spleen Cells during Secondary Response. Nature 218, 377–378 (1968). https://doi.org/10.1038/218377a0

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