Abstract
LYMPH node cells of immunized rabbit have been shown to produce not only whole molecules of immunoglobulins (Ig), but also an excess of L-chains1–3. Other data suggest a small pool of light chains with a rapid turnover4. Rabbit spleen cells have also been found to synthesize a micro-globulin with antigenic determinants of both light and heavy chains in vitro2,3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Shapiro, A. L., Scharff, M. D., Maizel, J. V., and Uhr, J. W., Nature, 211, 243 (1966).
Nezlin, R. S., and Kulpina, L. W., Nature, 212, 845 (1966).
Nezlin, R. S., and Kulpina, L. W., Biochimija (USSR), 31, 1257 (1966).
Askonas, B. A., and Williamson, A. R., Nature, 211, 369 (1966).
Gurvich, A. E., and Drizlikh, G. I., Mol. Biol. (USSR), 1, 279 (1967).
Andrews, P., Biochem. J., 91, 222 (1964).
Fleischman, J. B., Porter, R. R., and Press, E. M., Biochem. J., 88, 220 (1963).
Gurvich, A. E., and Sidorova, E. W., Biochimija (USSR), 29, 556 (1964).
Gurvich, A. E., and Drizlikh, G. I., Nature, 203, 648 (1964).
Bernier, G. M., and Cebra, J. J., J. Immunol., 95, 246 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SKVORTSOV, V., GURVICH, A. Relative Rates of Synthesis of Immunoglobulins and Light Chains in Rabbit Spleen Cells during Secondary Response. Nature 218, 377–378 (1968). https://doi.org/10.1038/218377a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/218377a0
This article is cited by
-
Combination of the 2A/furin technology with an animal component free cell line development platform process
Applied Microbiology and Biotechnology (2010)
-
Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses
Nature Medicine (2002)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.