Abstract
VISUALIZATION of layering phenomena in several light microscopic studies1–5 has given rise to the view that the retina matures morphologically in a centrifugal sequence from inner to outer layers, with ganglion cells maturing first and receptors last6. On the other hand, in a variety of species (mouse7, rat8, rabbit2, dog9, chick10 and frog11) in which the order of appearance of light-evoked electroretinographic wave forms has been followed through the developmental period, the a-wave, which is believed to arise at an outer retinal level12,13, could be elicited several days earlier than the b-wave which is believed to arise at an inner retinal level14–16. A centripetal sequence of at least certain aspects of functional maturation, from outer to inner levels of the retina, is suggested by these data.
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OLNEY, J. Centripetal Sequence of Appearance of Receptor–Bipolar Synaptic Structures in Developing Mouse Retina. Nature 218, 281–282 (1968). https://doi.org/10.1038/218281a0
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DOI: https://doi.org/10.1038/218281a0
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