Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Aureolic Acid Group of Anti-tumour Antibiotics

Abstract

SINCE 1953 several antibiotics of similar biological and physico-chemical properties have been described. These are aureolic acid1, aburamycin2, LA-7017 (ref. 3), M5-18903 (ref. 4), chromomycin5, antibiotic 2410 (ref. 6), NSC A-649 (ref. 7), olivomycin8, mithramycin9 and antibiotics 232, 3014, 7193, 11296 (ref. 10) and SK-229 (ref. 11). Two members of this group, olivomycin and chromomycin, were subjected to extensive chemical research which resulted in the isolation and structural elucidation of their components, olivomycins A, B, C, D (ref. 12) and chromomycins A2, A3, A4 (ref. 13). The other members of the group, however, have been only scantily investigated.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Grundy, W. E., Goldstein, A. W., Rickher, C. J., Hanes, M. E., Warren, H. B., and Sylvester, J. C., Antibiot. Chemother., 3, 1215 (1953); Philip, J. E., and Schenck, J. R., ibid., 1218.

    CAS  Google Scholar 

  2. Nishimura, H., Kimura, T., Tawara, K., Sasaki, K., Nakajima, K., Shimaoka, N., Okamoto, S., Shimohira, M., and Isono, J., J. Antibiot. (Tokyo). Ser. A 10, 205 (1957).

    CAS  PubMed  Google Scholar 

  3. Sensi, P., Greco, A. M., and Pagani, H., Antibiot. Chemother., 8, 241 (1958).

    CAS  Google Scholar 

  4. Gale, R. M., Hoehn, M. M., and McCormick, M. H., Antibiot. Ann., 489 (1958).

  5. Shibata, M., Tanabe, K., Hamada, Y., Nakazawa, K., Miyake, A., Hitomi, M., Miyamoto, M., and Mizuno, K., J. Antibiot. (Tokyo), Ser. B 13, 1 (1960).

    CAS  Google Scholar 

  6. Bringi, N. V., Bhatt, V. V., and Thirumalachar, M. J., Hind. Antibiot. Bull., 2, 120 (1960).

    Google Scholar 

  7. Schmitz, H., Heinemann, B., Lein, J., and Hooper, I. R., Antibiot. Chemother., 10, 740 (1960).

    CAS  Google Scholar 

  8. Gauze, G. F., Ukholina, R. S., and Sveshnikova, M. A., Antibiotiki, 7 (3), 34 (1962); Brazhnikova, M. G., Kruglyak, E. B., Kovsharova, I. N., Konstantinova, N. V., and Proshlyakova, V. V., ibid., 39.

    CAS  Google Scholar 

  9. Rao, K. V., Cullen, W. P., and Sobin, B. A., Antibiot. Chemother., 12, 182 (1962).

    CAS  Google Scholar 

  10. Ukholina, R. S., Kruglyak, E. B., Borisova, V. N., Kovsharova, I. N., and Proshlyakova, V. V., Mikrobiologia, 34, 147 (1965).

    CAS  Google Scholar 

  11. Yoshida, T., Matsuura, S., Sunagawa, N., Suetomi, S., Kimura, Y., and Katagiri, K., Ann. Rep. Shionogi Res. Lab., 15, 212 (1965).

    Google Scholar 

  12. Berlin, Yu. A., Esipov, S. E., Kolosov, M. N., and Shemyakin, M. M., Tetrahedron Lett., 1431, 1643 (1966); Bakhaeva, G. P., Berlin, Yu. A., Chuprunova, O. A., Kolosov, M. N., Peck, G. Yu., Piotrovich, L. A., Shemyakin, M. M., and Vasina, I. V., Chem. Commun., 10 (1967).

  13. Miyamoto, M., Kawamatsu, Y., Kawashima, K., Shinohara, M., Tanaka, K., Tatsuoka, S., and Nakanishi, K., Tetrahedron, 23, 421 (1967).

    Article  CAS  Google Scholar 

  14. Brazhnikova, M. G., Kruglyak, E. B., Mezentsev, A. S., and Fedorova, G. B., Antibiotiki, 9, 552 (1964); Berlin, Yu. A., Esipov, S. E., Kolosov, M. N., Shemyakin, M. M., and Brazhnikova, M. G., Tetrahedron Lett., 1323 (1964).

    CAS  PubMed  Google Scholar 

  15. Miyamoto, M., Morita, K., Kawamatsu, Y., Noguchi, S., Marumoto, R., Tanaka, K., Tatsuoka, S., Nakanishi, K., Nakadaira, Y., and Bhacca, N. S., Tetrahedron Lett., 2355 (1964).

  16. Brazhnikova, M. G., Kruglyak, E. B., and Mezentsev, A. S., Antimicrob. Agents Chemother., 119 (1966).

  17. Kruglyak, E. B., Borisova, V. N., and Brazhnikova, M. G., Antibiotiki, 8, 1064 (1963).

    CAS  Google Scholar 

  18. Gauze, G. F., Maximova, T. S., Ukholina, R. S., Brazhnikova, M. G., and Kruglyak, E. B., Antibiotiki, 12 (12) (1967).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BERLIN, Y., KISELEVA, O., KOLOSOV, M. et al. Aureolic Acid Group of Anti-tumour Antibiotics. Nature 218, 193–194 (1968). https://doi.org/10.1038/218193a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/218193a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing