Abstract
IT has long been known1,2 that immunizing an animal with heterologous lymphoid tissue produces a serum which has a marked anti-lymphocytic effect in the species donating the lymphoid tissue. The wider significance of this finding was realized only recently, after injection of such anti-lymphocytic serum (ALS) had been shown3,4 to prolong greatly the survival of allografts. Although the potent immunosuppressive effect of ALS is now well established, elucidation of its mode of action is proving more difficult5–7.
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TUCKER, D. Effects of Anti-spleen Serum on Skin Allograft Survival and Blood Lymphocyte Reactivity in the Chicken. Nature 218, 1259–1261 (1968). https://doi.org/10.1038/2181259a0
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DOI: https://doi.org/10.1038/2181259a0
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