Abstract
THE mixed leucocyte interaction (MLI) occurs in an in vitro culture system in which immunological recognition between blood lymphocytes from genetically different donors can be detected and measured by blastoid transformation of these cells, increased mitotic rate or increased DNA synthesis. The phenomenon is usually considered to involve differences in transplantation antigens between the reacting cell populations. Although an immunological basis for the MLI has been shown with lymphocytes of human1–4, rat5–7 and dog8 origin, it would be advantageous to adapt this test to a model system such as the inbred mouse in which the genetic and antigenic basis of tissue graft rejection has been carefully investigated during the past 60 years. Such adaptation is reported here.
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MAIN, R., JONES, M. Mixed Leucocyte Interaction involving Mouse Strains of Strong and Weak Allogeneic Specificities. Nature 218, 1251–1252 (1968). https://doi.org/10.1038/2181251a0
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DOI: https://doi.org/10.1038/2181251a0
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