Abstract
MANY atopic allergens—the biologically active substances involved in the syndrome of atopy in man (asthma, hay fever, atopic eczema)—have been shown to incorporate 1-deoxy-2-ketose side chains attached at the sugar carbon C1 to the ε-amino groups of lysine residues in the peptide chain of the protein or glycoprotein carrier molecules1–3. Recent syntheses have shown that the selective coupling of reducing sugar to the ε-amino functions of lysine side chains in the β-lactoglobulin molecule does in fact increase the specific activity of the protein during skin tests in milk-sensitive individuals4. The blockade of a few amine or amide groups by combination with monosaccharides would also provide a plausible explanation for the occurrence of, and for the physicochemical difference between, the “iso-allergens” in extracts of grass pollen5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Berrens, L., and Bleumink, E., Intern. Arch. Allergy, 28, 150 (1965).
Berrens, L., Immunochemistry, 4, 37 (1967).
Berrens, L., Immunochemistry, 4, 81 (1967).
Bleumink, E., and Berrens, L., Nature, 212, 541 (1966).
Johnson, P., and Marsh, D. G., Nature, 206, 935 (1966).
Erdös, E. G., Yang, H. Y. T., Tague, L. L., and Manning, N., Biochem. Pharmacol., 16, 1287 (1967).
Hopsu-Havu, V. K., Mäkinen, K. K., and Glenner, G. G., Nature, 212, 1271 (1966).
Webster, M. E., and Pierce, J. V., Ann. NY Acad. Sci., 104, 91 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BERRENS, L. Inhibition of Leucine and Lysine Aminopeptidase by Atopic Allergens. Nature 217, 664–665 (1968). https://doi.org/10.1038/217664a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/217664a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.