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Relative Binding of Strontium and Calcium in Protein and Non-protein Fractions of Serum in the Rabbit

Abstract

WE have reported a discrimination between the ratio of strontium to calcium in rabbit plasma and that in bone1. We reasoned that this discrimination could be the result of a difference in this ratio in the protein and non-protein fractions of the plasma. If the ratio of strontium to calcium in the non-protein fractions was lower than that in the plasma as a whole, then the ratio in the extracellular fluid might be expected to be lower and hence account for the lower ratio which has been observed in bone. To test this hypothesis a double tracer experiment using strontium-85 and calcium-47 was carried out in two rabbits which were of the same strain and age (7 months) as those used before. The protein and non-protein fractions were separated in an ultracentrifuge and the ratio of strontium-85 to calcium-47 was determined for these fractions as well as for the whole serum. These measurements showed that the ratio was the same for all fractions within the limits of experimental error.

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References

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LLOYD, E. Relative Binding of Strontium and Calcium in Protein and Non-protein Fractions of Serum in the Rabbit. Nature 217, 355–356 (1968). https://doi.org/10.1038/217355a0

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