Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Relative Binding of Strontium and Calcium in Protein and Non-protein Fractions of Serum in the Rabbit


WE have reported a discrimination between the ratio of strontium to calcium in rabbit plasma and that in bone1. We reasoned that this discrimination could be the result of a difference in this ratio in the protein and non-protein fractions of the plasma. If the ratio of strontium to calcium in the non-protein fractions was lower than that in the plasma as a whole, then the ratio in the extracellular fluid might be expected to be lower and hence account for the lower ratio which has been observed in bone. To test this hypothesis a double tracer experiment using strontium-85 and calcium-47 was carried out in two rabbits which were of the same strain and age (7 months) as those used before. The protein and non-protein fractions were separated in an ultracentrifuge and the ratio of strontium-85 to calcium-47 was determined for these fractions as well as for the whole serum. These measurements showed that the ratio was the same for all fractions within the limits of experimental error.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Kshirsagar, S. G., Lloyd, E., and Vaughan, J., Brit. J. Radiol., 39, 131 (1966).

    Article  Google Scholar 

  2. 2

    Breen, M., and Freeman, S., Clin. Chim. Acta, 6, 181 (1961).

    CAS  Article  Google Scholar 

  3. 3

    Munday, K. A., and Mahy, B. W. J., Clin. Chim. Acta, 10, 144 (1964).

    CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

LLOYD, E. Relative Binding of Strontium and Calcium in Protein and Non-protein Fractions of Serum in the Rabbit. Nature 217, 355–356 (1968).

Download citation


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing