Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Gamma G4-Globulin Antibody causing Inhibition of Clotting Factor VIII

Abstract

HAEMOPHILIA results from the absence of clotting factor VIII. The presence of a circulating inhibitor to factor VIII causes a disease which resembles haemophilia. Five patients with inhibitors shown to be γG-antibodies have been reported1–3.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Erik Berntorp, Kathelijn Fischer, … Victor Blanchette

References

  1. Shapiro, S., J. Clin. Invest., 46, 147 (1967).

    Article  CAS  Google Scholar 

  2. Andersen, B. R., and Troup, S. B., J. Immunol. (in the press, 1968).

  3. Poulik, M. D., and Lusher, J., Fed. Proc., 26, 312 (1967).

    Google Scholar 

  4. Bull. WHO, 35, 953 (1966).

  5. Margolis, J., J. Clin. Pathol., 11, 406 (1958).

    Article  CAS  Google Scholar 

  6. Grey, H., and Kunkel, H., J. Bxp. Med., 120, 253 (1964).

    Article  CAS  Google Scholar 

  7. Terry, W. D., and Fahey, J. L., Science, 146, 400 (1964).

    Article  CAS  ADS  Google Scholar 

  8. Terry, W. D., J. Immunol., 95, 1041 (1965).

    CAS  PubMed  Google Scholar 

  9. Ishizaka, T., Ishizaka, K., Salmon, S., and Fudenberg, H., J. Immunol., 99, 82 (1967).

    CAS  PubMed  Google Scholar 

  10. Glueck, H., and Hong, R., J. Clin. Invest., 44, 1866 (1965).

    Article  CAS  Google Scholar 

  11. Harboe, H.,, van Furth, R., Schubothe, H., Lind, K., and Evans, S., Scand. J. Haematol., 2, 259 (1965).

    Article  CAS  Google Scholar 

  12. Leddy, J., and Bakemeier, R., J. Exp. Med., 121, 1 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ANDERSEN, B., TERRY, W. Gamma G4-Globulin Antibody causing Inhibition of Clotting Factor VIII. Nature 217, 174–175 (1968). https://doi.org/10.1038/217174a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/217174a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing