Abstract
ISOANTIGENS, thought to be important as histocompatibility antigens, have been identified on membranes of human cells by serological techniques1. In order to interpret serological studies of histocompatibility antigens in terms of an understanding of the molecular representation of gene information, the isoantigens must be obtained in a suitable state for detailed chemical analysis. Preparation of soluble isoantigen in relatively low molecular weight form would be an important step in this direction.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Amos, D. B., Transplantation, 5, 1015 (1967).
Leskowitz, S., Ann. Rev. Microbiol., 21, 157 (1967).
Kandutsch, A. A., and Stimpfling, J. H., Transplantation, 1, 201 (1963).
Kahan, B. D., Proc. US Nat. Acad. Sci., 55, 153 (1965).
Nathenson, S. G., and Davies, D. A. L., Proc. US Nat. Acad. Sci., 56, 476 (1966).
Nathenson, S. G., and Davies, D. A. L., Ann. NY Acad. Sci., 126, 6 (1966).
Edidin, M., Proc. US Nat. Acad. Sci., 57, 1226 (1967).
Shimada, A., and Nathenson, S. G., Biochim. Biophys. Res. Commun. (in the press).
Rogentine, G. N., and Plocinik, B., Transplantation, 5, 1323 (1967).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MANN, D., ROGENTINE, G., FAHEY, J. et al. Solubilization of Human Leucocyte Membrane Isoantigens. Nature 217, 1180–1181 (1968). https://doi.org/10.1038/2171180a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2171180a0
This article is cited by
-
Primary structure of a murine transplantation antigen
Nature (1981)
-
Cultured human lymphoid cells: Tools for the biological and molecular characterization of antigens and their recognition systems
In Vitro (1975)
-
Mitogene aktivit�t von melanomextrakten in leukocytenkulturen
Archives for Dermatological Research (1975)
-
Alteration of fibroblast gene products in vitro from a subject with Werner's syndrome
Nature (1974)
-
Detection of fungal spore antigens by serologic methods
Experientia (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.