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Solubilization of Human Leucocyte Membrane Isoantigens

Nature volume 217, pages 1180–1181 (1968)Cite this article

Abstract

ISOANTIGENS, thought to be important as histocompatibility antigens, have been identified on membranes of human cells by serological techniques1. In order to interpret serological studies of histocompatibility antigens in terms of an understanding of the molecular representation of gene information, the isoantigens must be obtained in a suitable state for detailed chemical analysis. Preparation of soluble isoantigen in relatively low molecular weight form would be an important step in this direction.

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References

  1. Amos, D. B., Transplantation, 5, 1015 (1967).

    Article  Google Scholar 

  2. Leskowitz, S., Ann. Rev. Microbiol., 21, 157 (1967).

    Article  CAS  Google Scholar 

  3. Kandutsch, A. A., and Stimpfling, J. H., Transplantation, 1, 201 (1963).

    Article  CAS  PubMed  Google Scholar 

  4. Kahan, B. D., Proc. US Nat. Acad. Sci., 55, 153 (1965).

    Article  ADS  Google Scholar 

  5. Nathenson, S. G., and Davies, D. A. L., Proc. US Nat. Acad. Sci., 56, 476 (1966).

    Article  ADS  CAS  Google Scholar 

  6. Nathenson, S. G., and Davies, D. A. L., Ann. NY Acad. Sci., 126, 6 (1966).

    ADS  Google Scholar 

  7. Edidin, M., Proc. US Nat. Acad. Sci., 57, 1226 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Shimada, A., and Nathenson, S. G., Biochim. Biophys. Res. Commun. (in the press).

  9. Rogentine, G. N., and Plocinik, B., Transplantation, 5, 1323 (1967).

    Article  PubMed  Google Scholar 

  10. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Immunology Branch, National Cancer Institute, Bethesda, Maryland

    DEAN L. MANN, G. NICHOLAS ROGENTINE JUN. & JOHN L. FAHEY

  2. Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York

    STANLEY G. NATHENSON

Authors
  1. DEAN L. MANN
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  2. G. NICHOLAS ROGENTINE JUN.
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  3. JOHN L. FAHEY
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  4. STANLEY G. NATHENSON
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MANN, D., ROGENTINE, G., FAHEY, J. et al. Solubilization of Human Leucocyte Membrane Isoantigens. Nature 217, 1180–1181 (1968). https://doi.org/10.1038/2171180a0

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