Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Immune Haemolysis: Reaction of the Terminal Complement Component

Abstract

THE lytic step of the complement reaction sequence is biologically very important. An attempt to determine its nature by indirect methods was previously made in this laboratory1,2. Another direct approach to the problem was conceived when it was shown that the “classical” third component of haemolytic complement (C′) comprises at least six distinct factors3,4.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Fischer, H., and Haupt, I., Z. Naturforsch., 16b, 321 (1961).

    Article  Google Scholar 

  2. Fischer, H., and Haupt, I., in Immunchemie (edit. by Westphal, O.), 284 (Springer, Heidelberg, 1965).

    Book  Google Scholar 

  3. Nelson, R. A., in The Inflammatory Process (edit. by Zweifach, B. W., Grant, L., and McCluskey, R. J.) (Academic Press, New York, 1965).

    Google Scholar 

  4. Klein, P. G., in Complement (edit. by Wolstenholme, G. E. W.), 34 (Churchill, London, 1965).

    Google Scholar 

  5. Complement Workshop, Immunochemistry, 3, 495 (1966).

    Article  Google Scholar 

  6. Lepow, I. H., and Leon, M. A., Immunology, 5, 222 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Mayer, M. M., in Experimental Immunochemistry, by Kabat, E., and Mayer, M. M., second ed. (Thomas, Springfield, 1961).

    Google Scholar 

  8. Wellensiek, H. J., and Klein, P. G., Immunology, 8, 604 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Klein, P. G., and Wellensiek, H. J., Immunology, 8, 590 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Götze, O., Zbl. Bakt. I Ref., 206, 551 (1967).

    Google Scholar 

  11. Stolfi, R., Fed. Proc., 26, 362 (1967).

    Google Scholar 

  12. Uriel, U., Bull. Soc. Chim. Biol., 48, 969 (1966).

    CAS  PubMed  Google Scholar 

  13. Hadding, U., Müller-Eberhard, H. J., and Dalmasso, A. P., Fed. Proc., 25, 485 (1966).

    Google Scholar 

  14. Mayer, M. M., in Immunochemical Approaches to Problems in Microbiology (edit. by Heidelberger, M., and Plescia, O. J.) (Rutgers University Press, New Brunswick, New Jersey, 1961).

    Google Scholar 

  15. Hadding, U., and Müller-Eberhard, H. J., Science, 157, 442 (1967).

    Article  ADS  CAS  Google Scholar 

  16. Frank, M. M., Rapp, H. J., and Borsos, T., J. Immunol., 93, 409 (1965).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GÖTZE, O., HAUPT, I. & FISCHER, H. Immune Haemolysis: Reaction of the Terminal Complement Component. Nature 217, 1165–1167 (1968). https://doi.org/10.1038/2171165a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2171165a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing