Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

DNA Restriction Enzyme from E. coli


An endonuclease which degrades foreign DNA has been isolated. The enzyme requires S-adenosylmethionine, ATP and Mg++.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Luria, S. E., Cold Spring Harbor Symp. Quant. Biol., 18, 237 (1953).

    CAS  Article  Google Scholar 

  2. 2

    Bertani, G., and Weigle, J. J., J. Bacteriol., 65, 113 (1953).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. 3

    Arber, W., Ann. Rev. Microbiol., 365 (1965).

  4. 4

    Colson, C., Glover, S. W., Symonds, N., and Stacey, K. A., Genetics, 52, 1043 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. 5

    Wood, W. B., J. Mol. Biol., 16, 118 (1966).

    CAS  Article  Google Scholar 

  6. 6

    Eskridge, R. W., Weingeld, H., and Paigen, K., J. Bacteriol., 93, 835 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. 7

    Kerszman, G., Glover, S. W., and Avonovitch, J., J. Gen. Virol., 1, 333 (1967).

    CAS  Article  Google Scholar 

  8. 8

    Arber, W., J. Mol. Biol., 11, 247 (1965).

    CAS  Article  Google Scholar 

  9. 9

    Klein, A., and Sauerbier, W., Biochem. Biophys. Res. Commun., 18, 440 (1965).

    CAS  Article  Google Scholar 

  10. 10

    Appleyard, R. K., Genetics, 39, 440 (1954).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. 11

    Okada, T., Homma, J., and Sonohara, H., J. Bact., 84, 602 (1962).

    CAS  PubMed  Google Scholar 

  12. 12

    Durwald, H., and Hoffman-Berling, H., J. Mol. Biol. (in the press).

  13. 13

    Meselson, M., J. Mol. Biol., 9, 734 (1964).

    CAS  Article  Google Scholar 

  14. 14

    Kaiser, A. D., Virology, 3, 42 (1957).

    CAS  Article  Google Scholar 

  15. 15

    Hradecna, Z., and Szybalski, W., Virology, 32, 633 (1967).

    CAS  Article  Google Scholar 

  16. 16

    Kaiser, A. D., and Hogness, D. S., J. Mol. Biol., 2, 392 (1960).

    CAS  Article  Google Scholar 

  17. 17

    Studier, F. W., J. Mol. Biol., 11, 373 (1965).

    CAS  Article  Google Scholar 

  18. 18

    Bode, V. C., and Kaiser, A. D., J. Mol. Biol., 14, 399 (1965).

    CAS  Article  Google Scholar 

  19. 19

    Heinemann, S., dissert., Harvard Univ. (1967).

  20. 20

    Takano, T., Watanabe, T., and Fukasawa, T., Biochem. Biophy. Res. Commun., 25, 192 (1966).

    CAS  Article  Google Scholar 

  21. 21

    Arber, W., Hattman, S., and Dussoix, D., Virology, 21, 30 (1963).

    CAS  Article  Google Scholar 

  22. 22

    Lederberg, S., and Meselson, M., J. Mol. Biol., 8, 623 (1964).

    CAS  Article  Google Scholar 

  23. 23

    Lehman, I. R., Ann. Rev. Biochem., 36, 645 (1967).

    CAS  Article  Google Scholar 

  24. 24

    Boyer, H., J. Bact., 88, 1652 (1964).

    CAS  PubMed  Google Scholar 

  25. 25

    Lark, C., J. Mol. Biol., 31, 401 (1968).

    CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

MESELSON, M., YUAN, R. DNA Restriction Enzyme from E. coli. Nature 217, 1110–1114 (1968).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing