Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Respiration in Myocardium

Abstract

The qO2 or oxygen uptake of a tissue is considered to be a reflexion of the metabolic energy produced through substrate catabolism to support its functional activities. It is usually accepted that the total in vivo oxygen consumption is directly related to ATP production as the sole energy transfer and storage mechanism for endergonic processes1. Energy balance calculations in biology make use of this assumption, which is based on the known in vitro efficiencies of these processes. Recently biochemists have shown that certain non-mitochondrial enzyme systems assimilate or “take up” oxygen2 and that respiration without phosphorylation is probably essential to many of the biological functions of mitochondria3. The relative contribution of non-phosphorylating and non-mitochondrial oxygen uptake to total respiration in vivo has been studied in the isolated perfused rat heart. Oligomycin and cyanide were used as inhibitors to distinguish mitochondrial but non-phosphorylating respiration from non-mitochondrial respiration.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. White, A., Handler, P., and Smith, E., Principles of Biochemistry, chap. 16, 17 (McGraw Hill, New York, 1964).

    Google Scholar 

  2. Siekvitz, P., Fed. Proc., 24, 1153 (1965).

    Google Scholar 

  3. Control of Energy Metabolism (edit. by Chance, B.) (Academic Press, New York, 1965).

    Chapter  Google Scholar 

  4. Morgan, H. E., Henderson, M. J., Regen, D. M., and Park, C. P., J. Biol. Chem., 236, 253 (1961).

    CAS  PubMed  Google Scholar 

  5. Challoner, D. R., and Steinberg, D., Amer. J. Physiol., 210, 280 (1966).

    CAS  PubMed  Google Scholar 

  6. Challoner, D. R., and Steinberg, D., Amer. J. Physiol., 211, 897 (1966).

    CAS  Google Scholar 

  7. Opie, L. H., J. Physiol., 180, 529 (1965).

    Article  CAS  Google Scholar 

  8. Huijing, F., and Slater, E. C., J. Biochem. Tokyo, 49, 493 (1961).

    Article  CAS  Google Scholar 

  9. Lardy, H. A., Johnson, D., and McMurry, W. C., Biochemistry, 3, 1961 (1964).

    Article  CAS  Google Scholar 

  10. Challoner, D. R., Amer. J. Physiol. (in the press).

  11. Van Rossum, G. D., Biochim. Biophys. Acta, 82, 556 (1964).

    Article  CAS  Google Scholar 

  12. Wojtczak, L. H., Zaluska, L. H., and Drahota, Z., Biochim. Biophys. Acta, 98, 8 (1965).

    Article  CAS  Google Scholar 

  13. Beattie, D. S., and Basford, R. E., J. Biol. Chem., 241, 1412 (1966).

    CAS  PubMed  Google Scholar 

  14. Kroon, A. M., Biochim. Biophys. Acta, 72, 391 (1963).

    Article  CAS  Google Scholar 

  15. Etnster, L., and Lee, C. P., Ann. Rev. Biochem., 33, 779 (1964).

    Google Scholar 

  16. Azzone, G. F., and Azzi, A., Proc. US Nat. Acad. Sci., 53, 1984 (1965).

    Article  Google Scholar 

  17. Challoner, D. R., Lancet, ii, 681 (1966).

  18. Scholz, R., and Bucher, T., in Control of Energy Metabolism (edit. by Chance, B.), 393 (Academic Press, New York, 1965).

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

CHALLONER, D. Respiration in Myocardium. Nature 217, 78–79 (1968). https://doi.org/10.1038/217078a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/217078a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing