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Respiration in Myocardium


The qO2 or oxygen uptake of a tissue is considered to be a reflexion of the metabolic energy produced through substrate catabolism to support its functional activities. It is usually accepted that the total in vivo oxygen consumption is directly related to ATP production as the sole energy transfer and storage mechanism for endergonic processes1. Energy balance calculations in biology make use of this assumption, which is based on the known in vitro efficiencies of these processes. Recently biochemists have shown that certain non-mitochondrial enzyme systems assimilate or “take up” oxygen2 and that respiration without phosphorylation is probably essential to many of the biological functions of mitochondria3. The relative contribution of non-phosphorylating and non-mitochondrial oxygen uptake to total respiration in vivo has been studied in the isolated perfused rat heart. Oligomycin and cyanide were used as inhibitors to distinguish mitochondrial but non-phosphorylating respiration from non-mitochondrial respiration.

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  1. White, A., Handler, P., and Smith, E., Principles of Biochemistry, chap. 16, 17 (McGraw Hill, New York, 1964).

    Google Scholar 

  2. Siekvitz, P., Fed. Proc., 24, 1153 (1965).

    Google Scholar 

  3. Control of Energy Metabolism (edit. by Chance, B.) (Academic Press, New York, 1965).

    Chapter  Google Scholar 

  4. Morgan, H. E., Henderson, M. J., Regen, D. M., and Park, C. P., J. Biol. Chem., 236, 253 (1961).

    CAS  PubMed  Google Scholar 

  5. Challoner, D. R., and Steinberg, D., Amer. J. Physiol., 210, 280 (1966).

    CAS  PubMed  Google Scholar 

  6. Challoner, D. R., and Steinberg, D., Amer. J. Physiol., 211, 897 (1966).

    CAS  Google Scholar 

  7. Opie, L. H., J. Physiol., 180, 529 (1965).

    Article  CAS  Google Scholar 

  8. Huijing, F., and Slater, E. C., J. Biochem. Tokyo, 49, 493 (1961).

    Article  CAS  Google Scholar 

  9. Lardy, H. A., Johnson, D., and McMurry, W. C., Biochemistry, 3, 1961 (1964).

    Article  CAS  Google Scholar 

  10. Challoner, D. R., Amer. J. Physiol. (in the press).

  11. Van Rossum, G. D., Biochim. Biophys. Acta, 82, 556 (1964).

    Article  CAS  Google Scholar 

  12. Wojtczak, L. H., Zaluska, L. H., and Drahota, Z., Biochim. Biophys. Acta, 98, 8 (1965).

    Article  CAS  Google Scholar 

  13. Beattie, D. S., and Basford, R. E., J. Biol. Chem., 241, 1412 (1966).

    CAS  PubMed  Google Scholar 

  14. Kroon, A. M., Biochim. Biophys. Acta, 72, 391 (1963).

    Article  CAS  Google Scholar 

  15. Etnster, L., and Lee, C. P., Ann. Rev. Biochem., 33, 779 (1964).

    Google Scholar 

  16. Azzone, G. F., and Azzi, A., Proc. US Nat. Acad. Sci., 53, 1984 (1965).

    Article  Google Scholar 

  17. Challoner, D. R., Lancet, ii, 681 (1966).

  18. Scholz, R., and Bucher, T., in Control of Energy Metabolism (edit. by Chance, B.), 393 (Academic Press, New York, 1965).

    Book  Google Scholar 

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CHALLONER, D. Respiration in Myocardium. Nature 217, 78–79 (1968).

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