Suppression of Experimental Allergic Encephalomyelitis in Mice by Irradiation of the Target Organ

Abstract

THE pathogenesis of experimental allergic encephalomyelitis (EAE) is not definitely known and yet it is frequently used as an experimental model for the study of autoimmune disease of the central nervous system. Waksman contends that the principal event giving rise to EAE after injection of the antigen is the passage of immunologically competent cells or histiocytes through small venules into the nervous system1. These cells originate in the blood stream and are held responsible for the destruction of elements containing antigen in the central nervous system by an undefined mechanism. It has been found that EAE can be suppressed, either by generalized physical or chemical cytotoxic agents, or by destruction of the regional lymph nodes draining the inoculation site2–9. This communication reports the suppressive effect of localized irradiation of the brain in mice during the induction of EAE, and compares the effect with that of total body irradiation.

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SCHEINBEBG, L., LEE, J. & TAYLOR, J. Suppression of Experimental Allergic Encephalomyelitis in Mice by Irradiation of the Target Organ. Nature 216, 924–925 (1967). https://doi.org/10.1038/216924a0

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