Obligate Cation Exchanges in Red Cells

Abstract

COUPLING between the movements of sodium out of, and potassium into, human erythrocytes was discussed some time ago1. Although the concept of coupling between the active movements of sodium and potassium ions has been widely accepted2,3 it has been less usual to regard the down gradient “leak” movements as coupled. The stoichiometry of the active process met the difficulty that more sodium ions are extruded than potassium ions gained. To maintain electro-neutrality some other ion must move in association with potassium and sodium ions; this process has been somewhat neglected.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Harris, E. J., Symp. Soc. Exp. Biol., 8, 228 (1954).

  2. 2

    Post, R. L., and Jolly, P. C., Biochem. Biophys. Acta, 25, 118 (1957).

  3. 3

    Hoffman, J. F., and Kregenow, F. M., Ann. NY Acad. Sci., 137, 566 (1966).

  4. 4

    Chappell, B., and Crofts, A., in Regulation of Metabolic Processes in Mitochondria (edit. by Tager, J. M., Papa, S., Quagliariello, E., and Slater, E. C.) (Elsevier Publishing Co., Amsterdam, 1965).

  5. 5

    Rosenberg, T., and Wilbrandt, W., J. Gen. Physiol., 41, 289 (1957).

  6. 6

    Mueller, P., and Rudin, D. O., Biochem. Biophys. Res. Comm., 26, 398 (1967).

  7. 7

    Skulachev, V. P., Abstract Seventh International Biochem. Cong., Tokyo, 305 (1967).

  8. 8

    Chappell, J. B., and Haarhoff, K. N., in Biochemistry of Mitochondria (edit. by Slater, E. C., Kanigua, Z., and Wojtczak, L.), 75 (Academic Press, New York, 1966).

  9. 9

    Pressman, B. C., Harris, E. J., Jaeger, W. S., and Johnson, J. H., Proc. US Nat. Acad. Sci. (in the press).

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HARRIS, E., PRESSMAN, B. Obligate Cation Exchanges in Red Cells. Nature 216, 918–920 (1967). https://doi.org/10.1038/216918a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.