Abstract
VARIANTS of human haemoglobin A with an electrophoretic mobility identical with Hb-S at pH 8.6, but not causing sickling, are designated HbD. This type of haemoglobin has been found in many widely separated geographical localities1. In six cases the haemoglobins D were structurally identical with the substitution glutamic acid→glutamine at position 121 of the β-chain2,3. These samples were obtained from a Punjabi, a Caucasian from North Carolina, an Italian family living in Chicago, a Portuguese, a Greek Cypriot and a white family living in Los Angeles in whom Hb-S was also present.
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WADE, P., JENKINS, T. & HUEHNS, E. Haemoglobin Variant in a Bushman: Haemoglobin Dβ-Bushmanαβ2216Gly→Arg. Nature 216, 688–690 (1967). https://doi.org/10.1038/216688b0
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DOI: https://doi.org/10.1038/216688b0
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