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Reproductive Death of Irradiated Cultured Mammalian Cells and its relation to Mitosis

Abstract

A CLOSE relationship between mitosis and cell death has been demonstrated in rat retina1, and similar observations have been made on various other cell systems. This type of cell death has often been called “mitotic death” or “division death”, emphasizing its relationship to mitosis or division. Lately, this type of death has been called “reproductive death”, stressing loss of reproductive integrity2. It should be mentioned that all terms, including “metabolic death”3, express only part of the characteristics of cell death, but none to the satisfaction of everyone. Knowing the shortcomings of these terms, “reproductive death” will be used, for the sake of convenience, for this type of cell death.

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WATANABE, I., OKADA, S. Reproductive Death of Irradiated Cultured Mammalian Cells and its relation to Mitosis. Nature 216, 380–381 (1967). https://doi.org/10.1038/216380a0

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