Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei

Abstract

STUDIES with avian malaria have shown that killed sporozoites as well as sporozoites inactivated with ultraviolet light can produce a partial immunity after injection into birds1,2. On the other hand, attempts to use the erythrocytic stages of the parasite as the source of antigen have met with only limited success with avian3, rodent4 and monkey malaria5,6. Previous attempts to use killed sporozoites of the rodent malarial parasite, Plasmodium berghei, to immunize rodents have been unsuccessful. We therefore sought to determine whether protective immunity to this parasite could be achieved by partial inactivation of the injected sporozoites as opposed to injection of dead parasites. X-irradiation was chosen as the inactivating agent, because of the partial immunity obtained by vaccination with irradiated blood forms of malaria parasites7–9. This communication reports preliminary results on the production of protective immunity in mice by vaccination with X-irradiated sporozoites of P. berghei.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Mulligan, H. W., Russell, P. F., and Mohan, B. N., J. Mal. Inst. Ind., 4, 25 (1941).

    Google Scholar 

  2. 2

    Richards, W. H. G., Nature, 212, 1492 (1966).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Freund, J., Sommer, H. E., and Walter, A. W., Science, 102, 200 (1945).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Zuckerman, A., Hamburger, Y., and Spira, D., Progress in Protozool., Second Intern. Conf. on Protozool., Abstract 41, 50 (London, 1965).

  5. 5

    Freund, J., Thomson, K. J., Sommer, H. E., Walter, A. W., and Schenkein, E. L., Science, 102, 202 (1945).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Targett, G. A. T., and Fulton, J. D., Exp. Parasitol., 17, 180 (1965).

    CAS  Article  Google Scholar 

  7. 7

    Ceithaml, J., and Evans, E. A., J. Inf. Dis., 78, 190 (1946).

    CAS  Article  Google Scholar 

  8. 8

    Corradetti, A., Verolini, F., and Bucci, A., Parassitologia, 8, 133 (1966).

    Google Scholar 

  9. 9

    Wellde, B., and Sadun, E. H., Exp. Parasitol., 20 (1967).

  10. 10

    Nussenzweig, R. S., Exp. Parasitol. (in the press, 1967).

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

NUSSENZWEIG, R., VANDERBERG, J., MOST, H. et al. Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei. Nature 216, 160–162 (1967). https://doi.org/10.1038/216160a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing