Binding of Cortisol to Human Albumin


AN investigation of the binding of cortisol to human plasma proteins led us to re-examine the interaction between cortisol and pure human albumin. Previous workers1–3 have obtained widely differing results for the percentage of cortisol which was bound by a given concentration of albumin, and Brunkhorst and Hess4 have suggested that the number of available binding sites/mole of albumin increases as the albumin solution is diluted. Our results confirm the quantitative findings of Chen et al.3 and suggest that some of the discrepancies in this field may be the result of experimental artefact.

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PEARSON, J., KEANE, P. & WALKER, W. Binding of Cortisol to Human Albumin. Nature 216, 1334–1335 (1967).

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