Study of the Ag(z) Factor

Abstract

THE existence of a genetically determined β-lipoprotein polymorphism in human serum was detected by Allison and Blumberg1 and Blumberg et al.2, employing a precipitating antibody which was present in the serum of a repeatedly transfused patient (C. de B.) The same antiserum was investigated by Hirschfeld et al.3 and was shown to contain at least three different anti-Ag antibodies against β-lipoprotein factors which were called Ag(a1), Ag(x), and Ag(z). Data on the genetics of the Ag(x) and Ag(a1) factors were reported by different authors4–6 who used monospecific anti-Ag(x) and anti-Ag(a1) sera. Only one other serum (C352) was found to possess anti-Ag(z) but it also had other anti-Ag specificities7. At present, the only source of anti-Ag(z) consists of serum from C. de B. absorbed with an Ag(x+a1+z−) serum. The complicating fact is that C. de B. seems to possess a fourth antibody8, so that absorption with Ag(x+a1+z−) sera may be unsuccessful in producing specific anti-Ag(z) antiserum. It can therefore be used in immunogenetic studies only with considerable caution.

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References

  1. 1

    Allison, A. C., and Blumberg, B. S., Lancet, i, 634 (1961).

  2. 2

    Blumberg, B. S., Dray, S., and Robinson, J. C., Nature, 194, 656 (1962).

    CAS  ADS  Article  Google Scholar 

  3. 3

    Hirschfeld, J., Blumberg, B. S., and Allison, A. C., Nature, 202, 706 (1964).

    CAS  ADS  Article  Google Scholar 

  4. 4

    Hirschfeld, J., and Blomback, M., Nature, 201, 1337 (1964).

    CAS  ADS  Article  Google Scholar 

  5. 5

    Rittner, Ch., Vox Sang., 12, 225 (1967).

    Article  Google Scholar 

  6. 6

    Morganti, G., Beolchini, P. E., Bütler, R., and Vierucci, A., Humangenetik (in the press).

  7. 7

    Hirschfeld, J., and Blumberg, B. S., Nature, 213, 1247 (1967).

    ADS  Article  Google Scholar 

  8. 8

    Smith, C. A. B., Ann. Hum. Genet., 20, 257 (1956).

    CAS  Article  Google Scholar 

  9. 9

    Hirschfeld, J., Hunger, P., and Ramgren, D., Nature, 212, 206 (1966).

    CAS  ADS  Article  Google Scholar 

  10. 10

    Hirschfeld, J., Series Haemat. (in the press).

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VIERUCCI, A., BLUMBERG, B. & MORGANTI, G. Study of the Ag(z) Factor. Nature 216, 1231–1232 (1967). https://doi.org/10.1038/2161231a0

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