Effect of Promethazine Hydrochloride on the Release of Gastrin in the Dog


ANTIHISTAMTNIC drugs do not inhibit acid secretion stimulated by histamine or insulin in the dog, but given intravenously they do suppress the secretory response to endogenous gastrin1,2. Payne et al.2, after testing several antihistamines, suggested that the specific pharmacological mechanism of this phenomenon was their atropine like (anticholinergic) effect. It is, however, difficult to reconcile this explanation with the fact that the vagal phase of acid secretion, stimulated by insulin hypo-glycaemia, was apparently unaffected by the antihistaminics1.

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  1. 1

    Ragins, H., Benditt, E. P., Greenlee, H. B., and Dragstedt, L. R., Gastroenterology, 35, 1 (1958).

  2. 2

    Payne, R. A., Naylor, F. D., and Kay, A. W., Brit. J. Surg., 48, 683 (1961).

  3. 3

    Woodward, E. R., Lyon, E. S., Landor, J., and Dragstedt, L. R., Gastroenterology, 27, 766 (1954).

  4. 4

    Lim, R. K. S., and Mozer, P., Amer. J. Physiol., 163, 730 (1950).

  5. 5

    Redford, M., and Schofield, B., Biochem. Pharmacol, 12, Suppl. 130 (1963).

  6. 6

    Gregory, R. A., and Tracy, H. J., J. Physiol., 156, 523 (1961).

  7. 7

    Elwin, C. E., and Uvnas, B., in Gastrin (edit. by Grossman, M. I.), 79 (U.C.L.A. Forum in Med. Sci. No. 5, University of California Press, 1966).

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DOMBRO, R., RAGINS, H. Effect of Promethazine Hydrochloride on the Release of Gastrin in the Dog. Nature 216, 1225–1226 (1967). https://doi.org/10.1038/2161225a0

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