Effect of Promethazine Hydrochloride on the Release of Gastrin in the Dog

Abstract

ANTIHISTAMTNIC drugs do not inhibit acid secretion stimulated by histamine or insulin in the dog, but given intravenously they do suppress the secretory response to endogenous gastrin1,2. Payne et al.2, after testing several antihistamines, suggested that the specific pharmacological mechanism of this phenomenon was their atropine like (anticholinergic) effect. It is, however, difficult to reconcile this explanation with the fact that the vagal phase of acid secretion, stimulated by insulin hypo-glycaemia, was apparently unaffected by the antihistaminics1.

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References

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DOMBRO, R., RAGINS, H. Effect of Promethazine Hydrochloride on the Release of Gastrin in the Dog. Nature 216, 1225–1226 (1967). https://doi.org/10.1038/2161225a0

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