Inhibition of Egg Implantation and Induction of Abortion in Mice by Heterologous Immune Serum

Abstract

IMMUNOLOGICAL, reactions between mother and conceptus play an important part during pregnancy. It has, for example, been shown that placental size1–3, foetal size4 and length of gestation4 can be influenced by the immunological relationship between mother and foetus. As early as implantation the mouse embryo is capable of expressing transplantation antigens and the mother can react to them5,6. Mouse eggs which are genetically most dissimilar from the mother are more readily implanted7. This is also true of the rat (personal communication from W. K. Silvers and D. Wilson). It has been suggested that immunological selection of eggs at implantation might be a contributory determinant of sex ratio8.

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KIRBY, D. Inhibition of Egg Implantation and Induction of Abortion in Mice by Heterologous Immune Serum. Nature 216, 1220–1221 (1967). https://doi.org/10.1038/2161220a0

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