Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Protein Synthesis in Tonic and Phasic Skeletal Muscles

Abstract

LITTLE is known of the way in which physiological function influences protein metabolism in muscle. Knowledge in this area is essential if we are to understand the biochemical mechanisms through which use and disuse alter muscle size and functional capacity. The present studies were undertaken to see if the level of protein synthesis in different skeletal muscles varies systematically with different types of physiological activity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ranvier, L., Lecons d'Anatomie Générale sur le Système Musculaire (Paris, Delahaye, 1880).

  2. Denny-Brown, D., Proc. Roy. Soc. London, B, 104, 371 (1929).

    ADS  Google Scholar 

  3. Dubowitz, F., and Pearse, A. G. E., Histochemie, 2, 105 (1960); Romanul, F. C. A., Arch. Neurol., 11; 355 (1964); Dawson, D. M., and Romanul, F. C. A., ibid., 11, 368 (1964).

    Article  CAS  Google Scholar 

  4. Henneman, E., and Olson, C. B., J. Neurophysiol., 28, 581 (1965); Henneman, E., Somjan, G., and Carpenter, D. O., ibid., 28, 561 (1965).

    Article  CAS  Google Scholar 

  5. Goldberg, A. L., Amer. J. Physiol., 215, 1193 (1967).

    Article  Google Scholar 

  6. Christensen, H. N., Biological Transport (Benjamin, New York, 1962).

    Book  Google Scholar 

  7. Goldberg, A. L., J. Cell Biol. (in the press).

  8. Streter, F. A., and Woo, G., Amer. J. Physiol., 205, 1290 (1963).

    Article  Google Scholar 

  9. Randle, P., Energy Metabolism and Body Fuel Utilization (edit. by Morgan, A. P.) (Harvard University Printing Office, Cambridge, Mass., 1966); Zierler, K., ibid. Krebs, H. A., in Advances in Enzyme Regulation (edit. by Weber, G.), 385 (Pergamon Press, 1963).

    Google Scholar 

  10. Schmidt, G., and Tannhauser, S., J. Biol. Chem., 161, 83 (1945); Munro, H. N., and Fleck, A., in Methods of Biochemical Analysis (edit. by Glick, D.), 14, 113 (Interscience Publishers, New York, 1966).

    Google Scholar 

  11. Margreth, A., and Novello, F., Exp. Cell Res., 35, 38 (1964).

    Article  CAS  Google Scholar 

  12. Peterson, R. P., Science, 153, 1413 (1966).

    Article  ADS  CAS  Google Scholar 

  13. Goldberg, A. L., and Goodman, H. M., Fed. Proc., 26, 1358 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GOLDBERG, A. Protein Synthesis in Tonic and Phasic Skeletal Muscles. Nature 216, 1219–1220 (1967). https://doi.org/10.1038/2161219a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2161219a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing