Effect of Hydrocortisone on the Closure of Palatal Shelves in vivo and in vitro


SINCE the first experiments of Fraser and Fainstat1 in 1951, it has become clear that cortisone induces cleft palate in mice when administered before the closure of the palatal shelves. Certain direct and indirect effects on the palatal tissue have been suggested, in cluding the effect of cortisone on the turnover of the amniotic fluid2–4. Harris4 postulated that oligohydramnion, resulting from maternal cortisone treatment, affects the normal development of the palatal region by constricting the embryo. Recently, however, Fraser et al.5 have compared the amount of amniotic fluid in embryos treated with cortisone with and without cleft palate. Ko differences were detected and the results seem to rule out the possibility that oligohydramnion plays a part in the genesis of cleft palate.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Fraser, F. C., and Fainstat, T. D., Pediatrics, 8, 527 (1951).

  2. 2

    Larsson, K. S., Acta Morphol. Neerl. Scand., 4, 369 (1962).

  3. 3

    Jacobs, R. M., Anat. Rec., 156, 1 (1966).

  4. 4

    Harris, J. W. S., Nature, 203, 533 (1964).

  5. 5

    Fraser, F. C., Chew, D., and Verrusio, A. C., Nature, 214, 417 (1967).

  6. 6

    Fraser, F. C., First Intern. Conf. Congr. Malf. Philadelphia, 179 (J. B. Lippincott, 1961).

  7. 7

    Fraser, F. C., Teratology, 21 (The University of Chicago Press, Chicago, 1965).

  8. 8

    Walker, B. E., and Fraser, F. C., J. Embryol. Exp. Morph., 4, 176 (1956).

  9. 9

    Moriarty, T. M., Weinstein, S., and Gibson, R. D., J. Embryol. Exp. Morph., 11, 605 (1963).

  10. 10

    Konegni, J. S., Chan, B. C., Moriarty, T. M., Weinstein, S., and Gibson, R. D., Cleft Palate J., 2, 219 (1965).

  11. 11

    Portois, M., J. Embryol. Exp. Morph., 16, 171 (1966).

  12. 12

    Reeve, W. L., Porter, K., and Lefkowitz, W., J. Dent. Res., 45, 1375 (1966).

  13. 13

    Myers, G. S., Petrakis, N. L., and Lee, M., Arch. Oral Biol., 12, 565 (1967).

  14. 14

    Pinsky, L., and Digeorge, A. M., Science, 147, 402 (1965).

  15. 15

    Saxén, L., J. Exp. Zool., 162, 269 (1966).

  16. 16

    Biggers, J. D., Gwatkin, R. B. L., and Heyner, S., Exp. Cell Res., 25, 41 (1961).

  17. 17

    Jeffrey, J. J., and Martin, G. R., Biochim. Biophys. Acta, 121, 269 (1966).

  18. 18

    Saxén, L., Science, 153, 1384 (1966).

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

LAHTI, A., SAXÉN, L. Effect of Hydrocortisone on the Closure of Palatal Shelves in vivo and in vitro. Nature 216, 1217–1218 (1967). https://doi.org/10.1038/2161217a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.