Bidirectional Transport of Radioactively Labelled Axoplasmic Components

Abstract

IT is well established that axoplasm moves somatofugally from the neurone cell body toward the axon terminals1. Somatofugal axoplasmic transport was first demonstrated by Weiss and Hiscoe2, who found that if a peripheral nerve was constricted the axons proximal to the site of constriction became engorged with axoplasm. Recent variations of these experiments have shown that certain axoplasmic components (acetylcholinesterase1, catechol-amine storage granules3 and labelled phospholipids4) accumulate distal as well as proximal to the constriction. This tendency for axoplasmic components to accumulate on both sides of a lesion in a nerve has been interpreted as support for the idea that axoplasmic components move along the axons both from the cell body toward the axon terminals and back in the direction of the cell body.

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References

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LASEK, R. Bidirectional Transport of Radioactively Labelled Axoplasmic Components. Nature 216, 1212–1214 (1967). https://doi.org/10.1038/2161212a0

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