Altered Duration of DNA Synthesis and Cell Cycle in Non-target Tissues of Mice treated with Oestrogen


THE effects of ovarian hormones on the cell cycle of target tissues have been extensively studied. It has been shown that high doses of oestrogens of exogenous origin can alter the duration of DNA synthesis (S phase) in target tissues when administered alone1,2 or in association with progesterone3.

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GALAND, P., RODESCH, F., LEROY, F. et al. Altered Duration of DNA Synthesis and Cell Cycle in Non-target Tissues of Mice treated with Oestrogen. Nature 216, 1211–1212 (1967).

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