Pink Spot, p-Tyramine and Schizophrenia


BOULTON et al.1, using monodimensional paper chromatography, confirmed the presence of the pink spot in urines of some schizophrenic and Parkinsonian patients and claimed that it was not caused by 3,4-dimethoxy-β-phenylethylamine (DMPEA) but by p-tyramine. It has been suggested2 that the much discussed pink spot may have been caused by p-tyramine and, furthermore, that this compound may be causally related to schizophrenia or Parkinson's disease. With regard to these suggestions, it might be pertinent to consider some of our findings which were obtained with urines from normal subjects and from chronic schizophrenic patients.

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VOGEL, W., AHLBERG, C., DI CARLO, V. et al. Pink Spot, p-Tyramine and Schizophrenia. Nature 216, 1038–1039 (1967).

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