Abstract
PERKOFF1 has recently emphasized the paucity of information on myoglobin metabolism and the importance of this haemoprotein in the myoglobinurias. Previous attempts to study the turnover of myoglobin by administering 14C-glycine-2 to rats met with limited success because of the poor incorporation of isotope and non-specific labelling of the molecule (that is, haem and globin). We now describe a new technique for preparing 3H-myoglobin labelled with haem and studies of its turnover and degradation are reported.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Perkoff, G. T., Amer. J. Med., 39, 527 (1965).
Lester, R., and Klein, P. D., J. Lab. Clin. Med., 67, 1000 (1966).
Morgan, V. E., J. Biol. Chem., 112, 557 (1936).
Gondko, R., Schmidt, M., and Leyko, W., Biochim. Biophys. Acta, 86, 191 (1964).
Cameron, B. F., Azzam, S. A., Kotite, L., and Awad, E. S., J. Lab. Clin. Med., 65, 883 (1965).
Rossi-Fanelli, A., Antonini, E., and Caputo, A., Biochim. Biophys. Acta, 30, 608 (1958).
Falk, J. E., Porphyrins and Metalloporphyrins, 240 (Elsevier Publishing Co., Amsterdam, 1964).
Bray, G. A., Anal. Biochem., 1, 279 (1960).
Awad, E. S., Cameron, B. F., and Kotite, L., Nature, 198, 1201 (1963).
Antonini, E., Physiol. Rev., 45, 123 (1965).
Ostrow, J. D., Hammaker, L., and Schmid, R., J. Clin. Invest., 40, 1442 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DALY, J., LITTLE, J., TROXLER, R. et al. Metabolism of 3H-Myoglobin. Nature 216, 1030–1031 (1967). https://doi.org/10.1038/2161030a0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1038/2161030a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
