Immune Cross-reactivity of Penicillin and Cephalothin

Abstract

WE recently described positive direct Coombs tests in patients receiving sodium cephalothin1. Because most normal sera caused the in vitro agglutination of red cells coated with cephalothin, we concluded that some of the positive direct Coombs tests must be related to non-immune binding of a serum protein–cephalothin complex to the red cell surface. We also suggested the possibility that some of these test sera contained anti-penicillin agglutinins.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Gralnick, H. R., Wright, L., and McGinniss, M., J. Amer. Med. Assoc., 199, 725 (1967).

  2. 2

    Drug Letter II: Report of a Drug Reaction, Bull. Hopkins Hospital, 118, 352 (1966).

  3. 3

    Rothschild, P. D., and Doty, D. B., J. Amer. Med. Assoc., 196, 372 (1966).

  4. 4

    Grieco, M. H., Arch. Intern. Med., 119, 141 (1967).

  5. 5

    Van Arsdale, P. P., et al., J. Amer. Med. Assoc., 185, 584 (1963).

  6. 6

    Thiel, J. A., et al., J. Allergy, 35, 399 (1964).

  7. 7

    Levine, B. B., et al., JCI, 45, 1895 (1966).

  8. 8

    Ley, A. B., et al., Science, 127, 1118 (1958).

  9. 9

    Marcuse, P. M., and Francis, B. J., Amer. J. Clin. Path., 34, 225 (1960).

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

GRALNICK, H., MCGINNISS, M. Immune Cross-reactivity of Penicillin and Cephalothin. Nature 216, 1026–1027 (1967). https://doi.org/10.1038/2161026a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.