Immune Cross-reactivity of Penicillin and Cephalothin


WE recently described positive direct Coombs tests in patients receiving sodium cephalothin1. Because most normal sera caused the in vitro agglutination of red cells coated with cephalothin, we concluded that some of the positive direct Coombs tests must be related to non-immune binding of a serum protein–cephalothin complex to the red cell surface. We also suggested the possibility that some of these test sera contained anti-penicillin agglutinins.

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GRALNICK, H., MCGINNISS, M. Immune Cross-reactivity of Penicillin and Cephalothin. Nature 216, 1026–1027 (1967).

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