Inhibition of Haemaggregation by Lepromin and Other Mycobacterial Substances

Abstract

HUMAN erythrocytes suspended in glucose buffered at about pH 5–5.8 may aggregate and this aggregation can be detected by the rapid settling of cells in a tube or by the pattern of deposit in a tube or plastic haemagglutination plate. The haemaggregation is inhibited by sodium chloride and quite specifically by polioviruses, by influenza viruses1 and by other biologically active substances including nucleic acids, mucoproteins, tuberculin and rhinoviruses2. Old tuberculin and purified protein (derivative) inhibit the haemaggregation of untreated erythrocytes, but certain viruses inhibit only erythrocytes treated with trypsin. The inhibition caused by tuberculin is correlated with skin sensitizing activity and is inhibited by specific antibody3,4.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Drescher, J., and Schrader, K., Amer. J. Hyg., 79, 218 (1964).

    CAS  PubMed  Google Scholar 

  2. 2

    Tyrrell, D. A. J., Head, B., and Dimic, M., Brit. J. Exp. Path., 48, 513 (1966).

    Google Scholar 

  3. 3

    Drescher, J., and Gillissen, A., Zbl. F. Bakt. I. Orig., 200, 480 (1966).

    CAS  Google Scholar 

  4. 4

    Gillissen, G., and Drescher, J., Zbl. F. Bakt. I. Orig., 201, 65 (1966).

    CAS  Google Scholar 

  5. 5

    WHO Tech. Rep. Ser., No. 71, 23 (1953).

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

GOODWIN, C., TYRRELL, D., HEAD, B. et al. Inhibition of Haemaggregation by Lepromin and Other Mycobacterial Substances. Nature 216, 1019–1020 (1967). https://doi.org/10.1038/2161019a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.