Inhibition of Haemaggregation by Lepromin and Other Mycobacterial Substances


HUMAN erythrocytes suspended in glucose buffered at about pH 5–5.8 may aggregate and this aggregation can be detected by the rapid settling of cells in a tube or by the pattern of deposit in a tube or plastic haemagglutination plate. The haemaggregation is inhibited by sodium chloride and quite specifically by polioviruses, by influenza viruses1 and by other biologically active substances including nucleic acids, mucoproteins, tuberculin and rhinoviruses2. Old tuberculin and purified protein (derivative) inhibit the haemaggregation of untreated erythrocytes, but certain viruses inhibit only erythrocytes treated with trypsin. The inhibition caused by tuberculin is correlated with skin sensitizing activity and is inhibited by specific antibody3,4.

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GOODWIN, C., TYRRELL, D., HEAD, B. et al. Inhibition of Haemaggregation by Lepromin and Other Mycobacterial Substances. Nature 216, 1019–1020 (1967).

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