Abstract
SEVERAL observations taken together support the suggestion that the pancreatic β-cell responds in different ways to an oral glucose meal and to an intravenous infusion of glucose. (1) Oral glucose produces a greater rise in concentrations of plasma insulin than does an identical intravenous load1,2; (2) oral glucose provokes a response in plasma insulin four or five times greater than that achieved by infusing glucose intravenously to comparable concentrations of blood glucose3; (3) epinephrine blunts the release of insulin usually encountered after intravenous infusion of glucose4, but fails to suppress the rise in concentrations of plasma insulin which follows an oral glucose meal5.
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NELSON, J., RABINOWITZ, D. & MERIMEE, T. Effect of Epinephrine on Insulin Release in Man induced by Secretin. Nature 215, 883–884 (1967). https://doi.org/10.1038/215883a0
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DOI: https://doi.org/10.1038/215883a0
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