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Evidence of Age Aneuploidy in the Chromosomes of the Sheep

Abstract

VARIATIONS in chromosome counts associated with age were first shown in human leucocyte cultures by Jacobs et al.1. I have examined the chromosomes of twenty-two normal ewes and rams and six freemartin sheep in preparations made by a method similar to that of Basrur and Gilman2, and have counted chromosomes in at least fifty metaphases in each case. Several cultures were prepared from each freemartin and were then counted to see if there was a relationship between XY cells and the degree of masculinization as reported before3,4; these results are reported elsewhere5. In none of the twenty-two normal sheep was any chromosome abnormality observed; in the freemartin sheep, however, there was XX and XY white blood cell chimaerism. The chromosome counts of the six freemartin sheep are recorded in Table 1 and the percentage of hypomodal and hypermodal modal cells in each of these are given in Table 2.

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References

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BRUERE, A. Evidence of Age Aneuploidy in the Chromosomes of the Sheep. Nature 215, 658–659 (1967). https://doi.org/10.1038/215658a0

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